Genomic screen for loci associated with alcohol dependence in mission indians

Cindy L. Ehlers, David A. Gilder, Tamara L. Wall, Evelyn Phillips, Heidi Feiler, Kirk C. Wilhelmsen

Research output: Contribution to journalArticle

94 Citations (Scopus)

Abstract

Alcohol dependence is a leading cause of morbidity and mortality in Native Americans, yet biological factors underlying the disorder in this ethnic group remain illusive. This study's aims were to map susceptibility loci for DSM-III-R alcohol dependence and two narrower alcohol-related phenotypes in Mission Indian families. Each participant gave a blood sample and completed an interview using the Semi-Structured Assessment for the Genetics of Alcoholism (SSAGA) that was used to make alcohol dependence diagnoses and the narrower phenotypes of withdrawal, and drinking severity. Genotypes were determined for a panel 791 microsatellite polymorphisms. Analyses of multipoint variance component LOD scores for the dichotomous DSM-III-R phenotype revealed no peak LOD scores that exceeded 2.0 at any chromosome location. Two chromosomes, 4 and 12, had peak LOD scores that exceeded 2 for the alcohol use severity phenotype and three chromosomes 6, 15, 16 were found to have peaks with LOD scores that exceeded 2 for the withdrawal phenotype. Evidence for linkage to chromosomes 4 and 15, and 16 have been reported previously for alcohol related phenotypes whereas no evidence has as yet been reported for chromosomes 6 and 12. Combined linkage and association analysis suggest that alcohol dehydrogenase 1B gene polymorphisms are partially responsible for the linkage result on chromosome 4 in this population. These results corroborate the importance of several chromosomal regions high-lighted in prior segregation studies in alcoholism and further identify new regions of the genome that may be unique to either the restricted phenotypes evaluated or this population of Mission Indians.

Original languageEnglish (US)
Pages (from-to)110-115
Number of pages6
JournalAmerican Journal of Medical Genetics - Neuropsychiatric Genetics
Volume129 B
Issue number1
StatePublished - Aug 15 2004
Externally publishedYes

Fingerprint

Alcoholism
Phenotype
Chromosomes, Human, Pair 4
Chromosomes, Human, Pair 15
Chromosomes, Human, Pair 12
Chromosomes, Human, Pair 6
Alcohols
Diagnostic and Statistical Manual of Mental Disorders
Chromosomes, Human, Pair 16
North American Indians
Alcohol Dehydrogenase
Biological Factors
Ethnic Groups
Microsatellite Repeats
Population
Drinking
Analysis of Variance
Chromosomes
Genotype
Genome

Keywords

  • Alcohol dehydrogenase
  • Alcohol withdrawal
  • Alcoholism
  • Linkage analysis
  • Native American

ASJC Scopus subject areas

  • Genetics(clinical)
  • Neuropsychology and Physiological Psychology
  • Neuroscience(all)

Cite this

Ehlers, C. L., Gilder, D. A., Wall, T. L., Phillips, E., Feiler, H., & Wilhelmsen, K. C. (2004). Genomic screen for loci associated with alcohol dependence in mission indians. American Journal of Medical Genetics - Neuropsychiatric Genetics, 129 B(1), 110-115.

Genomic screen for loci associated with alcohol dependence in mission indians. / Ehlers, Cindy L.; Gilder, David A.; Wall, Tamara L.; Phillips, Evelyn; Feiler, Heidi; Wilhelmsen, Kirk C.

In: American Journal of Medical Genetics - Neuropsychiatric Genetics, Vol. 129 B, No. 1, 15.08.2004, p. 110-115.

Research output: Contribution to journalArticle

Ehlers, CL, Gilder, DA, Wall, TL, Phillips, E, Feiler, H & Wilhelmsen, KC 2004, 'Genomic screen for loci associated with alcohol dependence in mission indians', American Journal of Medical Genetics - Neuropsychiatric Genetics, vol. 129 B, no. 1, pp. 110-115.
Ehlers, Cindy L. ; Gilder, David A. ; Wall, Tamara L. ; Phillips, Evelyn ; Feiler, Heidi ; Wilhelmsen, Kirk C. / Genomic screen for loci associated with alcohol dependence in mission indians. In: American Journal of Medical Genetics - Neuropsychiatric Genetics. 2004 ; Vol. 129 B, No. 1. pp. 110-115.
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