Genomic amplicons target vesicle recycling in breast cancer

Gordon B. Mills, Igor Jurisica, Yosef Yarden, Jim C. Norman

    Research output: Contribution to journalComment/debate

    28 Scopus citations

    Abstract

    Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

    Original languageEnglish (US)
    Pages (from-to)2123-2127
    Number of pages5
    JournalJournal of Clinical Investigation
    Volume119
    Issue number8
    DOIs
    StatePublished - Aug 3 2009

    ASJC Scopus subject areas

    • Medicine(all)

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