Genomic amplicons target vesicle recycling in breast cancer

Gordon B. Mills; Igor Jurisica; Yosef Yarden; Jim C. Norman

doi:10.1172/JCI40256

Genomic amplicons target vesicle recycling in breast cancer

Gordon B. Mills, Igor Jurisica, Yosef Yarden, Jim C. Norman

Research output: Contribution to journal › Comment/debate › peer-review

33 Scopus citations

Abstract

Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

Original language	English (US)
Pages (from-to)	2123-2127
Number of pages	5
Journal	Journal of Clinical Investigation
Volume	119
Issue number	8
DOIs	https://doi.org/10.1172/JCI40256
State	Published - Aug 3 2009
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1172/JCI40256

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title = "Genomic amplicons target vesicle recycling in breast cancer",

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AU - Jurisica, Igor

AU - Yarden, Yosef

AU - Norman, Jim C.

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AB - Aberrant endocytosis, vesicle targeting, and receptor recycling represent emerging hallmarks of cancer. In this issue of the JCI, Zhang and colleagues demonstrate that RAB-coupling protein (RCP; also known as RAB11FIP1) is a "driver" of the 8p11-12 amplicon in human breast cancer and mouse xenograft models of mammary carcinogenesis (see the related article beginning on page 2171). Their finding that RAB GTPase function enables genomic amplification to confer aggressiveness to mammary tumors adds significantly to the body of evidence supporting pivotal roles for receptor trafficking in the proliferation and metastasis of cancer.

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Genomic amplicons target vesicle recycling in breast cancer

Abstract

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