Genitourinary malignancy and pseudohyperparathyroidism

Genitourinary tumors account for half of all documented cases of pseudohyperparathyroidism. The treatment of hypercalcemia is directed towards immediate corection of the electrolyte imbalance and long-term control. These goals are accomplished with volume repletion, calcium normalization and removal of the tumor. Effective therapy includes saline infusion and furosemide. Additional control is obtained with phosphates and/or indomethacin. In refractory cases actinomycin-D or mithramycin is helpful. The first reported case of urethral cancer and second reported case of testicular seminoma producing this syndrome are added to the literature.