Genetics of ethanol-induced locomotor activation: Detection of QTLs in a C57BL/6J x DBA/2J F2 intercross

Robert Hitzemann, Laura Cipp, Kristin Demarest, Elham Mahjubi, James McCaughran

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Moderate doses of ethanol (1-2 g/kg) markedly increase locomotor activity in some inbred mouse strains, for example, the DBA/2J (D2), but have relatively little effect in other strains, for example, the C57BL/6J (B6). In the present study, we conducted a genome-wide search in a B6D2 F2 intercross (N = 925) for quantitative trait loci (QTLs) associated with the locomotor response. A QTL with a LOD score of 8.4 was detected on Chromosome (Chr) 2; this QTL accounted for 11.4% of the phenotypic variance and approximately 30% of the genetic variance. The QTL on Chr 2 is in the same general region as QTLs previously described for ethanol preference/consumption (Rodriguez et al. Alcohol Clin Exp Res 19, 367, 1995; Melo et al. Nat Genet 13, 147, 1996; Phillips et al. Mamm Genome, in press), acute ethanol withdrawal (Buck et al. J. Neurosci 17, 3946, 1997) and nitrous oxide withdrawal severity (Belknap et al. Behav Genet 23, 213, 1993). A logical candidate gene in the region of interest is the enzyme which synthesizes GABA, glutamic acid decarboxylase 1 (GadI).

Original languageEnglish (US)
Pages (from-to)956-962
Number of pages7
JournalMammalian Genome
Volume9
Issue number12
DOIs
StatePublished - 1998
Externally publishedYes

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Quantitative Trait Loci
Ethanol
Viverridae
Chromosomes, Human, Pair 2
Genome
Inbred Strains Mice
Glutamate Decarboxylase
Nitrous Oxide
Locomotion
gamma-Aminobutyric Acid
Alcohols
Enzymes
Genes

ASJC Scopus subject areas

  • Genetics

Cite this

Genetics of ethanol-induced locomotor activation : Detection of QTLs in a C57BL/6J x DBA/2J F2 intercross. / Hitzemann, Robert; Cipp, Laura; Demarest, Kristin; Mahjubi, Elham; McCaughran, James.

In: Mammalian Genome, Vol. 9, No. 12, 1998, p. 956-962.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Cipp, Laura ; Demarest, Kristin ; Mahjubi, Elham ; McCaughran, James. / Genetics of ethanol-induced locomotor activation : Detection of QTLs in a C57BL/6J x DBA/2J F2 intercross. In: Mammalian Genome. 1998 ; Vol. 9, No. 12. pp. 956-962.
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