Genetically obese zucker rats have abnormally low brain insulin content

Denis G. Baskin, Leslie J. Stein, Hitoshi Ikeda, Stephen C. Woods, Dianne P. Figlewicz, Daniel Porte, M. R C Greenwood, Daniel Dorsa

Research output: Contribution to journalArticle

106 Citations (Scopus)

Abstract

The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.

Original languageEnglish (US)
Pages (from-to)627-633
Number of pages7
JournalLife Sciences
Volume36
Issue number7
DOIs
StatePublished - Feb 18 1985
Externally publishedYes

Fingerprint

Zucker Rats
Rats
Brain
Insulin
Olfactory Bulb
Hypothalamus
Alleles
Rhombencephalon
Morbid Obesity
Mesencephalon
Amygdala
Cerebral Cortex
Hippocampus

ASJC Scopus subject areas

  • Pharmacology

Cite this

Baskin, D. G., Stein, L. J., Ikeda, H., Woods, S. C., Figlewicz, D. P., Porte, D., ... Dorsa, D. (1985). Genetically obese zucker rats have abnormally low brain insulin content. Life Sciences, 36(7), 627-633. https://doi.org/10.1016/0024-3205(85)90166-3

Genetically obese zucker rats have abnormally low brain insulin content. / Baskin, Denis G.; Stein, Leslie J.; Ikeda, Hitoshi; Woods, Stephen C.; Figlewicz, Dianne P.; Porte, Daniel; Greenwood, M. R C; Dorsa, Daniel.

In: Life Sciences, Vol. 36, No. 7, 18.02.1985, p. 627-633.

Research output: Contribution to journalArticle

Baskin, DG, Stein, LJ, Ikeda, H, Woods, SC, Figlewicz, DP, Porte, D, Greenwood, MRC & Dorsa, D 1985, 'Genetically obese zucker rats have abnormally low brain insulin content', Life Sciences, vol. 36, no. 7, pp. 627-633. https://doi.org/10.1016/0024-3205(85)90166-3
Baskin DG, Stein LJ, Ikeda H, Woods SC, Figlewicz DP, Porte D et al. Genetically obese zucker rats have abnormally low brain insulin content. Life Sciences. 1985 Feb 18;36(7):627-633. https://doi.org/10.1016/0024-3205(85)90166-3
Baskin, Denis G. ; Stein, Leslie J. ; Ikeda, Hitoshi ; Woods, Stephen C. ; Figlewicz, Dianne P. ; Porte, Daniel ; Greenwood, M. R C ; Dorsa, Daniel. / Genetically obese zucker rats have abnormally low brain insulin content. In: Life Sciences. 1985 ; Vol. 36, No. 7. pp. 627-633.
@article{3687152ec7034a35b942bff395e92c9a,
title = "Genetically obese zucker rats have abnormally low brain insulin content",
abstract = "The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.",
author = "Baskin, {Denis G.} and Stein, {Leslie J.} and Hitoshi Ikeda and Woods, {Stephen C.} and Figlewicz, {Dianne P.} and Daniel Porte and Greenwood, {M. R C} and Daniel Dorsa",
year = "1985",
month = "2",
day = "18",
doi = "10.1016/0024-3205(85)90166-3",
language = "English (US)",
volume = "36",
pages = "627--633",
journal = "Life Sciences",
issn = "0024-3205",
publisher = "Elsevier Inc.",
number = "7",

}

TY - JOUR

T1 - Genetically obese zucker rats have abnormally low brain insulin content

AU - Baskin, Denis G.

AU - Stein, Leslie J.

AU - Ikeda, Hitoshi

AU - Woods, Stephen C.

AU - Figlewicz, Dianne P.

AU - Porte, Daniel

AU - Greenwood, M. R C

AU - Dorsa, Daniel

PY - 1985/2/18

Y1 - 1985/2/18

N2 - The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.

AB - The concentration of immunoreactive insulin (IRI) extracted from the olfactory bulb, hypothalamus, hippocampus, cerebral cortex, amygdala, midbrain, and hindbrain was significantly lower in obese (fa/fa) and heterozygous (Fa/fa) Zucker rats in comparison to lean (Fa/Fa) Zucker rats. This deficit in brain IRI content was most severe in the hypothalamus and olfactory bulb and was independent of severe obesity since the marked reduction of brain IRI content was also found in heterozygous rats which possessed only one copy of the fa allele. These results demonstrate that in the 2-3 month-old female Zucker rat, the fa allele is associated with defective regulation of insulin in the brain.

UR - http://www.scopus.com/inward/record.url?scp=0021986560&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0021986560&partnerID=8YFLogxK

U2 - 10.1016/0024-3205(85)90166-3

DO - 10.1016/0024-3205(85)90166-3

M3 - Article

VL - 36

SP - 627

EP - 633

JO - Life Sciences

JF - Life Sciences

SN - 0024-3205

IS - 7

ER -