@article{d298c9aa3d0d4327bb733ee8848984a9,
title = "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease",
abstract = "Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P >.7). Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.",
keywords = "Cholesteryl ester transfer protein, Genetics, HDL-C, Instrumental variables, Single nucleotide polymorphisms",
author = "{International Genomics of Alzheimer's Project (IGAP)} and {ARUK Consortium} and {GERAD/PERADES, CHARGE, ADGC, EADI} and Peloso, {Gina M.} and {van der Lee}, {Sven J.} and R. Sims and {van der Lee}, {S. J.} and Naj, {A. C.} and C. Bellenguez and N. Badarinarayan and J. Jakobsdottir and Kunkle, {B. W.} and A. Boland and R. Raybould and Bis, {J. C.} and Martin, {E. R.} and B. Grenier-Boley and S. Heilmann-Heimbach and V. Chouraki and Kuzma, {A. B.} and K. Sleegers and M. Vronskaya and A. Ruiz and Graham, {R. R.} and R. Olaso and P. Hoffmann and Grove, {M. L.} and Vardarajan, {B. N.} and M. Hiltunen and N{\"o}then, {M. M.} and White, {C. C.} and Hamilton-Nelson, {K. L.} and J. Epelbaum and W. Maier and Choi, {S. H.} and Beecham, {G. W.} and C. Dulary and S. Herms and Smith, {A. V.} and Funk, {C. C.} and Derbois and Forstner, {A. J.} and S. Ahmad and H. Li and D. Bacq and D. Harold and Satizabal, {C. L.} and O. Valladares and A. Squassina and Kaye, {J. A.} and A. Pierce and Quinn, {J. F.} and Woltjer, {R. L.}",
note = "Funding Information: G.M. Peloso is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K01HL125751 . S.S. and A.L.D. are supported by grants from the National Institute on Aging : R01 AG054076 , R01 AG033193 , U01 AG049505 , R01 AG008122 (S. Seshadri), and R01AG049607 ) and the National Institute of Neurological Disorders and Stroke ( R01-NS017950 ). The authors thank all the participants and studies contributing to the GLGC and IGAP exome chip results. A full list of collaborators from the IGAP exome chip consortium is listed in the supplement. Publisher Copyright: {\textcopyright} 2018 The Authors",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.dadm.2018.08.008",
language = "English (US)",
volume = "10",
pages = "595--598",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
}