@article{d298c9aa3d0d4327bb733ee8848984a9,
title = "Genetically elevated high-density lipoprotein cholesterol through the cholesteryl ester transfer protein gene does not associate with risk of Alzheimer's disease",
abstract = "Introduction: There is conflicting evidence whether high-density lipoprotein cholesterol (HDL-C) is a risk factor for Alzheimer's disease (AD) and dementia. Genetic variation in the cholesteryl ester transfer protein (CETP) locus is associated with altered HDL-C. We aimed to assess AD risk by genetically predicted HDL-C. Methods: Ten single nucleotide polymorphisms within the CETP locus predicting HDL-C were applied to the International Genomics of Alzheimer's Project (IGAP) exome chip stage 1 results in up 16,097 late onset AD cases and 18,077 cognitively normal elderly controls. We performed instrumental variables analysis using inverse variance weighting, weighted median, and MR-Egger. Results: Based on 10 single nucleotide polymorphisms distinctly predicting HDL-C in the CETP locus, we found that HDL-C was not associated with risk of AD (P >.7). Discussion: Our study does not support the role of HDL-C on risk of AD through HDL-C altered by CETP. This study does not rule out other mechanisms by which HDL-C affects risk of AD.",
keywords = "Cholesteryl ester transfer protein, Genetics, HDL-C, Instrumental variables, Single nucleotide polymorphisms",
author = "{International Genomics of Alzheimer's Project (IGAP)} and {ARUK Consortium} and {GERAD/PERADES, CHARGE, ADGC, EADI} and Peloso, {Gina M.} and {van der Lee}, {Sven J.} and R. Sims and {van der Lee}, {S. J.} and Naj, {A. C.} and C. Bellenguez and N. Badarinarayan and J. Jakobsdottir and Kunkle, {B. W.} and A. Boland and R. Raybould and Bis, {J. C.} and Martin, {E. R.} and B. Grenier-Boley and S. Heilmann-Heimbach and V. Chouraki and Kuzma, {A. B.} and K. Sleegers and M. Vronskaya and A. Ruiz and Graham, {R. R.} and R. Olaso and P. Hoffmann and Grove, {M. L.} and Vardarajan, {B. N.} and M. Hiltunen and N{\"o}then, {M. M.} and White, {C. C.} and Hamilton-Nelson, {K. L.} and J. Epelbaum and W. Maier and Choi, {S. H.} and Beecham, {G. W.} and C. Dulary and S. Herms and Smith, {A. V.} and Funk, {C. C.} and Derbois and Forstner, {A. J.} and S. Ahmad and H. Li and D. Bacq and D. Harold and Satizabal, {C. L.} and O. Valladares and A. Squassina and Kaye, {J. A.} and A. Pierce and Quinn, {J. F.} and Woltjer, {R. L.}",
note = "Funding Information: G.M. Peloso is supported by the National Heart, Lung, and Blood Institute of the National Institutes of Health under award number K01HL125751. S.S. and A.L.D. are supported by grants from the National Institute on Aging: R01 AG054076, R01 AG033193, U01 AG049505, R01 AG008122 (S. Seshadri), and R01AG049607) and the National Institute of Neurological Disorders and Stroke (R01-NS017950). The authors thank all the participants and studies contributing to the GLGC and IGAP exome chip results. A full list of collaborators from the IGAP exome chip consortium is listed in the supplement.",
year = "2018",
month = jan,
day = "1",
doi = "10.1016/j.dadm.2018.08.008",
language = "English (US)",
volume = "10",
pages = "595--598",
journal = "Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring",
issn = "2352-8729",
publisher = "Elsevier BV",
}