Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication

Ronald L. Alkana; Deborah A. Finn; Marina Bejanian; John C. Crabbe

doi:10.1016/0024-3205(88)90570-X

Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication

Ronald L. Alkana, Deborah A. Finn, Marina Bejanian, John C. Crabbe

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

The present study investigated the importance of body temperature during intoxication in mediating differences between five inbred strains of mice (C57BL/6J; BALB/cJ; DBA/2J; A/HeJ; 129/J) in their acute sensitivity to the hypnotic effects of ethanol. Mice exposed to 22°C after ethanol injection became hypothermic and exhibited statistically significant differences between strains in rectal temperatures at the return of the righting reflex (RORR), duration of loss of the righting reflex (LORR), and blood and brain ethanol concentrations at RORR. Exposure to 34°C after injection offset ethanol-hypothermia and markedly reduced strain-related differences in rectal temperatures and blood and brain ethanol concentrations at RORR. Brain ethanol concentrations at RORR were significantly lower in C57, BALB, DBA and A/He mice exposed to 34°C compared to mice exposed to 22°C during intoxication suggesting that offsetting hypothermia increased ethanol sensitivity in these strains. Taken with previous in vitro studies, these results suggest that genetically determined differences in acute sensitivity to the behavioral effects of ethanol reflect differences in body temperature during intoxication as well as differences in sensitivity to the initial actions of ethanol at the cellular level.

Original language	English (US)
Pages (from-to)	1973-1982
Number of pages	10
Journal	Life Sciences
Volume	43
Issue number	24
DOIs	https://doi.org/10.1016/0024-3205(88)90570-X
State	Published - 1988

ASJC Scopus subject areas

General Pharmacology, Toxicology and Pharmaceutics
General Biochemistry, Genetics and Molecular Biology

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10.1016/0024-3205(88)90570-X

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title = "Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication",

abstract = "The present study investigated the importance of body temperature during intoxication in mediating differences between five inbred strains of mice (C57BL/6J; BALB/cJ; DBA/2J; A/HeJ; 129/J) in their acute sensitivity to the hypnotic effects of ethanol. Mice exposed to 22°C after ethanol injection became hypothermic and exhibited statistically significant differences between strains in rectal temperatures at the return of the righting reflex (RORR), duration of loss of the righting reflex (LORR), and blood and brain ethanol concentrations at RORR. Exposure to 34°C after injection offset ethanol-hypothermia and markedly reduced strain-related differences in rectal temperatures and blood and brain ethanol concentrations at RORR. Brain ethanol concentrations at RORR were significantly lower in C57, BALB, DBA and A/He mice exposed to 34°C compared to mice exposed to 22°C during intoxication suggesting that offsetting hypothermia increased ethanol sensitivity in these strains. Taken with previous in vitro studies, these results suggest that genetically determined differences in acute sensitivity to the behavioral effects of ethanol reflect differences in body temperature during intoxication as well as differences in sensitivity to the initial actions of ethanol at the cellular level.",

author = "Alkana, {Ronald L.} and Finn, {Deborah A.} and Marina Bejanian and Crabbe, {John C.}",

note = "Funding Information: Supported by PHS grant ROi AA05234 From the National Institute on Alcohol Abuse and Alcoholism to RLA. JCC is supported by the Veterans Administration and by PHS grants AA05828, AA06243 and AA06498. We thank Brenda Jones and Jeannie Chen for technlcal assistance and Drs. Peter J. Syapin, James R. West, Sandra J. Kelly, Linda K. A1kana and Robert F. McGivern for their comments and assistance with various aspects of the experiment.",

year = "1988",

doi = "10.1016/0024-3205(88)90570-X",

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pages = "1973--1982",

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T1 - Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication

AU - Alkana, Ronald L.

AU - Finn, Deborah A.

AU - Bejanian, Marina

AU - Crabbe, John C.

N1 - Funding Information: Supported by PHS grant ROi AA05234 From the National Institute on Alcohol Abuse and Alcoholism to RLA. JCC is supported by the Veterans Administration and by PHS grants AA05828, AA06243 and AA06498. We thank Brenda Jones and Jeannie Chen for technlcal assistance and Drs. Peter J. Syapin, James R. West, Sandra J. Kelly, Linda K. A1kana and Robert F. McGivern for their comments and assistance with various aspects of the experiment.

PY - 1988

Y1 - 1988

N2 - The present study investigated the importance of body temperature during intoxication in mediating differences between five inbred strains of mice (C57BL/6J; BALB/cJ; DBA/2J; A/HeJ; 129/J) in their acute sensitivity to the hypnotic effects of ethanol. Mice exposed to 22°C after ethanol injection became hypothermic and exhibited statistically significant differences between strains in rectal temperatures at the return of the righting reflex (RORR), duration of loss of the righting reflex (LORR), and blood and brain ethanol concentrations at RORR. Exposure to 34°C after injection offset ethanol-hypothermia and markedly reduced strain-related differences in rectal temperatures and blood and brain ethanol concentrations at RORR. Brain ethanol concentrations at RORR were significantly lower in C57, BALB, DBA and A/He mice exposed to 34°C compared to mice exposed to 22°C during intoxication suggesting that offsetting hypothermia increased ethanol sensitivity in these strains. Taken with previous in vitro studies, these results suggest that genetically determined differences in acute sensitivity to the behavioral effects of ethanol reflect differences in body temperature during intoxication as well as differences in sensitivity to the initial actions of ethanol at the cellular level.

AB - The present study investigated the importance of body temperature during intoxication in mediating differences between five inbred strains of mice (C57BL/6J; BALB/cJ; DBA/2J; A/HeJ; 129/J) in their acute sensitivity to the hypnotic effects of ethanol. Mice exposed to 22°C after ethanol injection became hypothermic and exhibited statistically significant differences between strains in rectal temperatures at the return of the righting reflex (RORR), duration of loss of the righting reflex (LORR), and blood and brain ethanol concentrations at RORR. Exposure to 34°C after injection offset ethanol-hypothermia and markedly reduced strain-related differences in rectal temperatures and blood and brain ethanol concentrations at RORR. Brain ethanol concentrations at RORR were significantly lower in C57, BALB, DBA and A/He mice exposed to 34°C compared to mice exposed to 22°C during intoxication suggesting that offsetting hypothermia increased ethanol sensitivity in these strains. Taken with previous in vitro studies, these results suggest that genetically determined differences in acute sensitivity to the behavioral effects of ethanol reflect differences in body temperature during intoxication as well as differences in sensitivity to the initial actions of ethanol at the cellular level.

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VL - 43

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JO - Life Sciences

JF - Life Sciences

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ER -

Genetically determined differences in ethanol sensitivity influenced by body temperature during intoxication

Abstract

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