Abstract
It is unknown whether or why genetic test reporting confers benefits in the understanding and management of cancer risk beyond what patients learn from counseling based on family history. A prospective nonexperimental control group study compared participants from melanoma-prone families who underwent CDKN2A/p16 (p16) genetic testing (27 carriers, 38 noncarriers) to participants from equivalently melanoma-prone families known not to carry a deleterious p16 mutation (31 no-test controls). All participants received equivalent counseling concerning elevated lifetime melanoma risk and corresponding recommendations for prevention and screening. Both immediately and 1 month after counseling, participants receiving a genetic test result reported greater understanding of their risk, decreased derogation of the risk information, and greater personal applicability of prevention recommendations than no-test controls. Decreased derogation of risk information after test reporting predicted further increases in understanding of melanoma risk and applicability of prevention recommendations 1 month later. Results suggest unique benefits of genetic test reporting in promoting understanding and acceptance of information about hereditary cancer risk and its management.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 740-753 |
| Number of pages | 14 |
| Journal | Journal of Behavioral Medicine |
| Volume | 38 |
| Issue number | 5 |
| DOIs | |
| State | Published - Jul 16 2015 |
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Keywords
- CDKN2A/p16
- Defensive processing
- Genetic testing
- Illness coherence
- Melanoma
- Understanding of risk
ASJC Scopus subject areas
- Psychology(all)
- Psychiatry and Mental health
Cite this
Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone. / Taber, Jennifer M.; Aspinwall, Lisa G.; Stump, Tammy K.; Kohlmann, Wendy; Champine, Marjan; Leachman, Sancy.
In: Journal of Behavioral Medicine, Vol. 38, No. 5, 16.07.2015, p. 740-753.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic test reporting enhances understanding of risk information and acceptance of prevention recommendations compared to family history-based counseling alone
AU - Taber, Jennifer M.
AU - Aspinwall, Lisa G.
AU - Stump, Tammy K.
AU - Kohlmann, Wendy
AU - Champine, Marjan
AU - Leachman, Sancy
PY - 2015/7/16
Y1 - 2015/7/16
N2 - It is unknown whether or why genetic test reporting confers benefits in the understanding and management of cancer risk beyond what patients learn from counseling based on family history. A prospective nonexperimental control group study compared participants from melanoma-prone families who underwent CDKN2A/p16 (p16) genetic testing (27 carriers, 38 noncarriers) to participants from equivalently melanoma-prone families known not to carry a deleterious p16 mutation (31 no-test controls). All participants received equivalent counseling concerning elevated lifetime melanoma risk and corresponding recommendations for prevention and screening. Both immediately and 1 month after counseling, participants receiving a genetic test result reported greater understanding of their risk, decreased derogation of the risk information, and greater personal applicability of prevention recommendations than no-test controls. Decreased derogation of risk information after test reporting predicted further increases in understanding of melanoma risk and applicability of prevention recommendations 1 month later. Results suggest unique benefits of genetic test reporting in promoting understanding and acceptance of information about hereditary cancer risk and its management.
AB - It is unknown whether or why genetic test reporting confers benefits in the understanding and management of cancer risk beyond what patients learn from counseling based on family history. A prospective nonexperimental control group study compared participants from melanoma-prone families who underwent CDKN2A/p16 (p16) genetic testing (27 carriers, 38 noncarriers) to participants from equivalently melanoma-prone families known not to carry a deleterious p16 mutation (31 no-test controls). All participants received equivalent counseling concerning elevated lifetime melanoma risk and corresponding recommendations for prevention and screening. Both immediately and 1 month after counseling, participants receiving a genetic test result reported greater understanding of their risk, decreased derogation of the risk information, and greater personal applicability of prevention recommendations than no-test controls. Decreased derogation of risk information after test reporting predicted further increases in understanding of melanoma risk and applicability of prevention recommendations 1 month later. Results suggest unique benefits of genetic test reporting in promoting understanding and acceptance of information about hereditary cancer risk and its management.
KW - CDKN2A/p16
KW - Defensive processing
KW - Genetic testing
KW - Illness coherence
KW - Melanoma
KW - Understanding of risk
UR - http://www.scopus.com/inward/record.url?scp=84941879707&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84941879707&partnerID=8YFLogxK
U2 - 10.1007/s10865-015-9648-z
DO - 10.1007/s10865-015-9648-z
M3 - Article
C2 - 26178773
AN - SCOPUS:84941879707
VL - 38
SP - 740
EP - 753
JO - Journal of Behavioral Medicine
JF - Journal of Behavioral Medicine
SN - 0160-7715
IS - 5
ER -