Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines

John C. Crabbe; Ann Kosobud; Emmett R. Young

doi:10.1016/0024-3205(83)90751-8

Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines

John C. Crabbe, Ann Kosobud, Emmett R. Young

Behavioral Neuroscience

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, and two control (WSC) lines are maintained. Each WSP line had more severe and each WSR line had less severe withdrawal convulsions than its respective WSC line. Differences relative to control lines were more pronounced in the WSP lines and were not due to differences in effective dose of ethanol. Heritabilities were higher in the WSP lines than in the WSR lines. These lines will be useful for studying physiological determinants of ethanol dependence and withdrawal.

Original language	English (US)
Pages (from-to)	955-962
Number of pages	8
Journal	Life Sciences
Volume	33
Issue number	10
DOIs	https://doi.org/10.1016/0024-3205(83)90751-8
State	Published - Sep 5 1983

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Pharmacology, Toxicology and Pharmaceutics(all)

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10.1016/0024-3205(83)90751-8

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title = "Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines",

abstract = "We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, and two control (WSC) lines are maintained. Each WSP line had more severe and each WSR line had less severe withdrawal convulsions than its respective WSC line. Differences relative to control lines were more pronounced in the WSP lines and were not due to differences in effective dose of ethanol. Heritabilities were higher in the WSP lines than in the WSR lines. These lines will be useful for studying physiological determinants of ethanol dependence and withdrawal.",

author = "Crabbe, {John C.} and Ann Kosobud and Young, {Emmett R.}",

note = "Funding Information: We thank J.K. Belknap for his advice and encouragement throughout the course of this project, and J. McSwigan and J.K. Belknap for critical readings of the manuscript. We also acknowledge the technical support of J. Janowsky, J. Stack, ~.A. Johnson, and H.M. Tesselaar; animal care support from P. Ellis, R.A. Shoemake and L. Long; and manuscript and graphic preparation by H. Bennett, A. Irwin, and L. Kitigawa. These studies were supported by the Veterans Administration and by USPHS Grant DA 02799 from the National Institute on Drug Abuse.",

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T2 - Differences in replicate mouse lines

AU - Crabbe, John C.

AU - Kosobud, Ann

AU - Young, Emmett R.

N1 - Funding Information: We thank J.K. Belknap for his advice and encouragement throughout the course of this project, and J. McSwigan and J.K. Belknap for critical readings of the manuscript. We also acknowledge the technical support of J. Janowsky, J. Stack, ~.A. Johnson, and H.M. Tesselaar; animal care support from P. Ellis, R.A. Shoemake and L. Long; and manuscript and graphic preparation by H. Bennett, A. Irwin, and L. Kitigawa. These studies were supported by the Veterans Administration and by USPHS Grant DA 02799 from the National Institute on Drug Abuse.

PY - 1983/9/5

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N2 - We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, and two control (WSC) lines are maintained. Each WSP line had more severe and each WSR line had less severe withdrawal convulsions than its respective WSC line. Differences relative to control lines were more pronounced in the WSP lines and were not due to differences in effective dose of ethanol. Heritabilities were higher in the WSP lines than in the WSR lines. These lines will be useful for studying physiological determinants of ethanol dependence and withdrawal.

AB - We report an ongoing within-family selective breeding project for the severity of handling-induced withdrawal seizures in mice made physically dependent on ethanol by inhalation. Two Withdrawal Seizure Prone (WSP) and two Withdrawal Seizure Resistant (WSR) lines have been subjected to five generations of selection, and two control (WSC) lines are maintained. Each WSP line had more severe and each WSR line had less severe withdrawal convulsions than its respective WSC line. Differences relative to control lines were more pronounced in the WSP lines and were not due to differences in effective dose of ethanol. Heritabilities were higher in the WSP lines than in the WSR lines. These lines will be useful for studying physiological determinants of ethanol dependence and withdrawal.

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Genetic selection for ethanol withdrawal severity: Differences in replicate mouse lines

Abstract

ASJC Scopus subject areas

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