Genetic polymorphisms in head and neck cancer risk

Jeffrey E. McWilliams, Adam J. Evans, Tomasz M. Beer, Peter E. Andersen, James I. Cohen, Edwin C. Everts, William David Henner

Research output: Contribution to journalArticle

74 Scopus citations

Abstract

Objective. To assess whether genetic polymorphisms implicated as risk factors for other tobacco-associated malignancies are associated with altered risk of head and neck squamous cell carcinoma. Design. Case-control study. Subjects. One hundred sixty patients with head and neck squamous cell carcinoma recruited from a university-based head and neck oncology clinic and 149 population-based controls. Methods. Genotyping of the CYP1A1 (Ile462Val), GSTM1 (null), GSTP1 (Ile105Val), GSTT1 (null), and P53 (Arg72Pro) genes was performed by polymerase chain reaction-based techniques on DNA prepared from peripheral blood. In addition, a questionnaire was used to collect demographic information from each subject. Results. Cases were significantly older (p < .0001) and had significantly greater tobacco use (p < .0001) and were more likely to be male (p < .0001) than were control subjects, thus confirming known risk factors for this disease. When cases and controls were compared by simple chi-square analysis, only the frequency of CYP1A1 (Ile462Val) polymorphism was significantly different between cases and controls (OR = .42; 95% Cl = .18-.99; p < .04). However, with a logistic regression model to control for known risk factors, we were unable to demonstrate a significant association with head and neck cancer for any of the polymorphisms tested, including CYP1A1. Conclusions. This population fails to identify a relationship between the above-mentioned polymorphisms and head and neck cancer. (C) 2000 John Wiley and Sons, Inc.

Original languageEnglish (US)
Pages (from-to)609-617
Number of pages9
JournalHead and Neck
Volume22
Issue number6
DOIs
StatePublished - Sep 12 2000

Keywords

  • CYP1A1
  • Epidemiology
  • GSTM1
  • GSTP1
  • GSTT1
  • Glutathione transferases
  • Head and neck cancer
  • P53

ASJC Scopus subject areas

  • Otorhinolaryngology

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