Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos

Dominick J. Lemas, Howard W. Wiener, Diane M. O'Brien, Scarlett Hopkins, Kimber L. Stanhope, Peter J. Havel, David B. Allison, Jose R. Fernandez, Hemant K. Tiwari, Bert B. Boyer

Research output: Contribution to journalArticle

49 Scopus citations

Abstract

Variants of carnitine palmitoyltransferase 1A (CPT1A), a key hepatic lipid oxidation enzyme, may influence how fatty acid oxidation contributes to obesity and metabolic outcomes. CPT1A is regulated by diet, suggesting interactions between gene variants and diet may influence outcomes. The objective of this study was to test the association of CPT1A variants with body composition and lipids, mediated by consumption of polyunsaturated fatty acids (PUFA). Obesity phenotypes and fasting lipids were measured in a cross-sectional sample of Yup'ik Eskimo individuals (n = 1141) from the Center of Alaska Native Health Research (CANHR) study. Twenty-eight tagging CPT1A SNPs were evaluated with outcomes of interest in regression models accounting for family structure. Several CPT1A polymorphisms were associated with HDL-cholesterol and obesity phenotypes. The P479L (rs80356779) variant was associated with all obesity-related traits and fasting HDL-cholesterol. Interestingly, the association of P479L with HDL-cholesterol was still significant after correcting for body mass index (BMI), percentage body fat (PBF), or waist circumference (WC). Our findings are consistent with the hypothesis that the L479 allele of the CPT1A P479L variant confers a selective advantage that is both cardioprotective (through increased HDL-cholesterol) and associated with reduced adiposity.

Original languageEnglish (US)
Pages (from-to)175-184
Number of pages10
JournalJournal of lipid research
Volume53
Issue number1
DOIs
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Biochemistry
  • Endocrinology
  • Cell Biology

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    Lemas, D. J., Wiener, H. W., O'Brien, D. M., Hopkins, S., Stanhope, K. L., Havel, P. J., Allison, D. B., Fernandez, J. R., Tiwari, H. K., & Boyer, B. B. (2012). Genetic polymorphisms in carnitine palmitoyltransferase 1A gene are associated with variation in body composition and fasting lipid traits in Yup'ik Eskimos. Journal of lipid research, 53(1), 175-184. https://doi.org/10.1194/jlr.P018952