Genetic mapping of the spinocerebellar ataxia type 2 gene on human chromosome 12

A. Nechiporuk, I. Lopes-Cendes, T. Nechiporuk, S. Starkman, E. Andermann, G. A. Rouleau, J. S. Weissenbach, E. Kort, S. M. Pulst

Research output: Contribution to journalArticlepeer-review

27 Scopus citations


The dominant spinocerebellar ataxias are a genetically heterogeneous group of diseases leading to premature death of neurons in the cerebellum and other parts of the nervous system. The mutation causing SCA1 is on human chromosome (CHR) 6p and SCA3 is on CHR 14q. To refine the location of the SCA2 gene on CHR 12q, we performed genetic linkage analysis between the SCA2 locus and nine loci (D12S58, D12S78, D12S317, D12S330, D12S353, D12S84, D12S105, D12S79, and PLA2) in three SCA2 families. The highest pairwise lod scores were obtained between SCA2 and D12S84/D12S105 and D12S79. We determined the best order and genetic distances among these loci in ten multigenerational families by multipoint linkage analysis and established the following order: D12S101-D12S58/IGF1-D12S78-D12S317-D12S330/D12S353-D12S84/D12S105-D12S79- PLA2. Using this genetic map, multipoint linkage analysis placed SCA2 between D12S84/D12S105 and D12S79.

Original languageEnglish (US)
Pages (from-to)1731-1735
Number of pages5
Issue number6
StatePublished - Jun 1996
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology


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