Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome

Eric J. Devor, David K. Grandy, Olivier Civelli, Michael Litl, Andrea K. Burgess, Keith E. Isenberg, B. J.M. Van De Wetering, Ben Oostra

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

Original languageEnglish (US)
Pages (from-to)105-108
Number of pages4
JournalHuman Heredity
Volume40
Issue number2
DOIs
StatePublished - 1990
Externally publishedYes

Keywords

  • Chromosome 11q
  • Linkage
  • Tourette syndrome

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

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