Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome

Eric J. Devor, David K. Grandy, Olivier Civelli, Michael Litl, Andrea K. Burgess, Keith E. Isenberg, B. J.M. Van De Wetering, Ben Oostra

    Research output: Contribution to journalArticle

    30 Scopus citations

    Abstract

    A genetic linkage study of fifteen families (n = 166) ascertained through probands diagnosed for Tourette syndrome was carried out for the D2dopamine receptor and flanking loci on chromosome 11q22-q23. Tight linkage was excluded for all probes and regions of exclusion up to ±20% recombination were obtained. Overlapping regions of exclusion based upon primary map data permit exclusion of the entire region of the DRD2 locus in Tourette syndrome.

    Original languageEnglish (US)
    Pages (from-to)105-108
    Number of pages4
    JournalHuman Heredity
    Volume40
    Issue number2
    DOIs
    StatePublished - Jan 1 1990

    Keywords

    • Chromosome 11q
    • Linkage
    • Tourette syndrome

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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    Devor, E. J., Grandy, D. K., Civelli, O., Litl, M., Burgess, A. K., Isenberg, K. E., Van De Wetering, B. J. M., & Oostra, B. (1990). Genetic linkage is excluded for the D2-dopamine receptor λHD2G1 and flanking loci on chromosome 11q22-q23 in tourette syndrome. Human Heredity, 40(2), 105-108. https://doi.org/10.1159/000153914