Genetic intersection of male infertility and cancer

Liina Nagirnaja, Kenneth I. Aston, Don Conrad

Research output: Contribution to journalReview article

7 Citations (Scopus)

Abstract

Recent epidemiological studies have identified an association between male factor infertility and increased cancer risk, however, the underlying etiology for the shared risk has not been investigated. It is likely that much of the association between the two disease states can be attributed to underlying genetic lesions. In this article we review the reported associations between cancer and spermatogenic defects, and through database searches we identify candidate genes and gene classes that could explain some of the observed shared genetic risk. We discuss the importance of fully characterizing the genetic basis for the relationship between cancer and male factor infertility and propose future studies to that end.

Original languageEnglish (US)
Pages (from-to)20-26
Number of pages7
JournalFertility and sterility
Volume109
Issue number1
DOIs
StatePublished - Jan 1 2018
Externally publishedYes

Fingerprint

Male Infertility
Neoplasms
Genes
Epidemiologic Studies
Databases

Keywords

  • Cancer
  • genetics
  • male infertility

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

Cite this

Genetic intersection of male infertility and cancer. / Nagirnaja, Liina; Aston, Kenneth I.; Conrad, Don.

In: Fertility and sterility, Vol. 109, No. 1, 01.01.2018, p. 20-26.

Research output: Contribution to journalReview article

Nagirnaja, Liina ; Aston, Kenneth I. ; Conrad, Don. / Genetic intersection of male infertility and cancer. In: Fertility and sterility. 2018 ; Vol. 109, No. 1. pp. 20-26.
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