Genetic differences in hypothalamic-pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal

Amanda J. Roberts, John Jr Crabbe, L. Donald Keith

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

There is a growing body of evidence suggesting that corticosteroids contribute to the increased neural excitability observed during ethanol withdrawal. In the present study, this was further investigated using mouse strains which differ in ethanol withdrawal severity. DBA/2 (DBA) mice were found to display more severe acute ethanol withdrawal seizures than C57BL/6 (C57) mice. Additionally, DBA mice showed a greater stress response than C57 mice, as measured by higher plasma concentations of adrenocorticotropic hormone (ACTH) and corticosterone, to an acute dose of ethanol. Mimicking withdrawal plasma corticosterone levels by administering corticosterone to ethanol-naive mice resulted in increases in handling-induced convulsions in the range observed during withdrawal. There did not appear to be a strain difference in sensitivity to the excitatory effects of corticosterone. In summary, the greater stress response to ethanol by DBA mice may account, in part, for the more severe ethanol withdrawal syndrome of this strain.

Original languageEnglish (US)
Pages (from-to)296-302
Number of pages7
JournalBrain Research
Volume579
Issue number2
DOIs
StatePublished - May 8 1992

Fingerprint

Ethanol
Corticosterone
Inbred DBA Mouse
Inbred C57BL Mouse
Seizures
Adrenocorticotropic Hormone
Adrenal Cortex Hormones

Keywords

  • Adrenocorticotropic hormone
  • Alcohol withdrawal
  • C57 inbred mouse strain
  • Convulsion
  • Corticosterone
  • DBA inbred mouse strain

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Genetic differences in hypothalamic-pituitary-adrenal axis responsiveness to acute ethanol and acute ethanol withdrawal. / Roberts, Amanda J.; Crabbe, John Jr; Donald Keith, L.

In: Brain Research, Vol. 579, No. 2, 08.05.1992, p. 296-302.

Research output: Contribution to journalArticle

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