Genetic determinants of circulating estrogen levels and evidence of a causal effect of estradiol on bone density in men

Anna L. Eriksson, John R.B. Perry, Andrea D. Coviello, Graciela E. Delgado, Luigi Ferrucci, Andrew R. Hoffman, Ilpo T. Huhtaniemi, M. Arfan Ikram, Magnus K. Karlsson, Marcus E. Kleber, Gail A. Laughlin, Yongmei Liu, Mattias Lorentzon, Kathryn L. Lunetta, Dan Mellström, Joanne M. Murabito, Anna Murray, Maria Nethander, Carrie Nielson, Inga ProkopenkoStephen R. Pye, Leslie J. Raffel, Fernando Rivadeneira, Priya Srikanth, Lisette Stolk, Alexander Teumer, Thomas G. Travison, André G. Uitterlinden, Dhananjay Vaidya, Dirk Vanderschueren, Joseph M. Zmuda, Winfried März, Eric S. Orwoll, Pamela Ouyang, Liesbeth Vandenput, Frederick C.W. Wu, Frank H. De Jong, Shalender Bhasin, Douglas P. Kiel, Claes Ohlsson

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Results: Variants in/near CYP19A1 demonstrated the strongest evidence for association with E2, resolving to three independent signals. Two additional independent signals were found on the X chromosome; FAMily with sequence similarity 9, member B (FAM9B), rs5934505 (P = 3.4 3 1028) and Xq27.3, rs5951794 (P = 3.1 3 10210). E1 signals were found in CYP19A1 (rs2899472, P = 5.5 3 10223), in Tripartite motif containing 4 (TRIM4; rs17277546, P = 5.8 3 10214), and CYP11B1/B2 (rs10093796, P = 1.2 3 1028). E2 signals in CYP19A1 and FAM9B were associated with bone mineral density (BMD). Mendelian randomization analysis suggested a causal effect of serum E2 on BMD in men. A 1 pg/mL genetically increased E2 was associated with a 0.048 standard deviation increase in lumbar spine BMD (P = 2.8 3 10212). In men and women combined, CYP19A1 alleles associated with higher E2 levels were associated with lower degrees of insulin resistance. Conclusions: Our findings confirm that CYP19A1 is an important genetic regulator of E2 and E1 levels and strengthen the causal importance of E2 for bone health in men. We also report two independent loci on the X-chromosome for E2, and one locus each in TRIM4 and CYP11B1/B2, for E1.

Original languageEnglish (US)
Pages (from-to)991-1004
Number of pages14
JournalJournal of Clinical Endocrinology and Metabolism
Issue number3
StatePublished - 2018

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical


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