Abstract
A major goal of pharmacogenetic research on alcoholism remains the identification of some "marker" that could predict the liability of a particular individual for a genetic susceptibility to develop alcoholism. The present paper presents evidence that the severity of withdrawal from physical dependence on ethanol varies widely among inbred strains of mice, and that withdrawal severity is negatively genetically correlated with initial sensitivity and magnitude of tolerance to ethanol hypothermia. These correlations are supported by differences in hypothermic response between replicate lines of mice genetically selected for susceptibility and resistance to ethanol withdrawal seizures. The genetic relationships reported suggest that the effects of ethanol on thermoregulation in mice may offer a predictive marker for susceptibility to ethanol physical dependence.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 541-547 |
| Number of pages | 7 |
| Journal | Pharmacology, Biochemistry and Behavior |
| Volume | 18 |
| Issue number | SUPPL. 1 |
| DOIs | |
| State | Published - 1983 |
| Externally published | Yes |
Fingerprint
Keywords
- Alcoholism
- Animal models
- Ethanol
- Ethanol withdrawal syndrome
- Genetic correlations
- Genetics
- Handling-induced convulsions
- Hypothermia
- Inbred mice
- Pharmacogenetics
- Tolerance
- WSP/WSR selectively-bred mouse lines
ASJC Scopus subject areas
- Biochemistry
- Behavioral Neuroscience
- Pharmacology
Cite this
Genetic correlations with ethanol withdrawal severity. / Crabbe, John Jr; Young, Emmett R.; Kosobud, Ann.
In: Pharmacology, Biochemistry and Behavior, Vol. 18, No. SUPPL. 1, 1983, p. 541-547.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic correlations with ethanol withdrawal severity
AU - Crabbe, John Jr
AU - Young, Emmett R.
AU - Kosobud, Ann
PY - 1983
Y1 - 1983
N2 - A major goal of pharmacogenetic research on alcoholism remains the identification of some "marker" that could predict the liability of a particular individual for a genetic susceptibility to develop alcoholism. The present paper presents evidence that the severity of withdrawal from physical dependence on ethanol varies widely among inbred strains of mice, and that withdrawal severity is negatively genetically correlated with initial sensitivity and magnitude of tolerance to ethanol hypothermia. These correlations are supported by differences in hypothermic response between replicate lines of mice genetically selected for susceptibility and resistance to ethanol withdrawal seizures. The genetic relationships reported suggest that the effects of ethanol on thermoregulation in mice may offer a predictive marker for susceptibility to ethanol physical dependence.
AB - A major goal of pharmacogenetic research on alcoholism remains the identification of some "marker" that could predict the liability of a particular individual for a genetic susceptibility to develop alcoholism. The present paper presents evidence that the severity of withdrawal from physical dependence on ethanol varies widely among inbred strains of mice, and that withdrawal severity is negatively genetically correlated with initial sensitivity and magnitude of tolerance to ethanol hypothermia. These correlations are supported by differences in hypothermic response between replicate lines of mice genetically selected for susceptibility and resistance to ethanol withdrawal seizures. The genetic relationships reported suggest that the effects of ethanol on thermoregulation in mice may offer a predictive marker for susceptibility to ethanol physical dependence.
KW - Alcoholism
KW - Animal models
KW - Ethanol
KW - Ethanol withdrawal syndrome
KW - Genetic correlations
KW - Genetics
KW - Handling-induced convulsions
KW - Hypothermia
KW - Inbred mice
KW - Pharmacogenetics
KW - Tolerance
KW - WSP/WSR selectively-bred mouse lines
UR - http://www.scopus.com/inward/record.url?scp=0021236681&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0021236681&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(83)90233-2
DO - 10.1016/0091-3057(83)90233-2
M3 - Article
C2 - 6685310
AN - SCOPUS:0021236681
VL - 18
SP - 541
EP - 547
JO - Pharmacology Biochemistry and Behavior
JF - Pharmacology Biochemistry and Behavior
SN - 0091-3057
IS - SUPPL. 1
ER -