Genetic components of ethanol responses

John Jr Crabbe, Daniel J. Feller, Erik S. Terdal, Catherine D. Merrill

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A powerful technique for determining the role of a particular neurotransmitter in mediating a response to ethanol (EtOH) is the analysis of selectively bred lines of animals. Lines selected for sensitivity and resistance to an EtOH effect differ principally in gene frequencies for genes affecting the selected response. Hence, other differences between the lines are likely due to pleiotropic actions of those genes. We discuss behavioral pharmacological experiments in two sets of selected lines. Withdrawal Seizure-Prone (WSP) and -Resistant(WSR) mouse lines were selected for severe and minimal handling-induced convulsions (HIC), respectively, after withdrawal from chronic EtOH inhalation. The HIC is also elevated after acute administration of low doses of convulsant drugs. WSP mice were found to be more sensitive than WSR mice to many such drugs. There was no apparent specificity of such effects to any particular neurotransmitter system. Thus, genetic determination of a behavioral response to EtOH in this case cannot be traced to the influence of a single neurotransmitter system. COLD and HOT mice were selectively bred to show severe and mild hypothermia, respectively, after acute EtOH administration. COLD mice are also more sensitive to a number of other alcohols, barbiturates, and other general central nervous system depressants. When tested for sensitivity to a number of drugs with specific effects on neurotransmitter systems, COLD and HOT mice did not differ in sensitivity to drugs affecting dopaminergic, α-adrenergic, or nicotinic acetylcholinergic systems, COLD mice were more sensitive, however, to opioid and serotonergic drugs. Thus, analysis of these selected lines was successful in identifying particular neurotransmitters which may be important in EtOH-induced hypothermia.

Original languageEnglish (US)
Pages (from-to)245-248
Number of pages4
JournalAlcohol
Volume7
Issue number3
DOIs
StatePublished - 1990
Externally publishedYes

Fingerprint

Neurotransmitter Agents
Ethanol
drug
Hypothermia
withdrawal
Seizures
seizure
Genes
Pharmaceutical Preparations
Central Nervous System Depressants
Serotonin Agents
Convulsants
Barbiturates
Adrenergic Agents
Induced Hypothermia
Opioid Analgesics
Dopamine Agents
Animals
animal
alcohol

Keywords

  • COLD/HOT mice
  • Convulsions
  • Ethanol
  • Hypothermia
  • Pharmacogenetics
  • Proconvulsant treatments
  • Selectively bred lines
  • Withdrawal
  • WSP/WSR mice

ASJC Scopus subject areas

  • Biochemistry
  • Medicine(all)
  • Neuroscience(all)
  • Behavioral Neuroscience
  • Toxicology
  • Health(social science)

Cite this

Crabbe, J. J., Feller, D. J., Terdal, E. S., & Merrill, C. D. (1990). Genetic components of ethanol responses. Alcohol, 7(3), 245-248. https://doi.org/10.1016/0741-8329(90)90013-3

Genetic components of ethanol responses. / Crabbe, John Jr; Feller, Daniel J.; Terdal, Erik S.; Merrill, Catherine D.

In: Alcohol, Vol. 7, No. 3, 1990, p. 245-248.

Research output: Contribution to journalArticle

Crabbe, JJ, Feller, DJ, Terdal, ES & Merrill, CD 1990, 'Genetic components of ethanol responses', Alcohol, vol. 7, no. 3, pp. 245-248. https://doi.org/10.1016/0741-8329(90)90013-3
Crabbe, John Jr ; Feller, Daniel J. ; Terdal, Erik S. ; Merrill, Catherine D. / Genetic components of ethanol responses. In: Alcohol. 1990 ; Vol. 7, No. 3. pp. 245-248.
@article{6f682befb6394edab33ca8caa81d6315,
title = "Genetic components of ethanol responses",
abstract = "A powerful technique for determining the role of a particular neurotransmitter in mediating a response to ethanol (EtOH) is the analysis of selectively bred lines of animals. Lines selected for sensitivity and resistance to an EtOH effect differ principally in gene frequencies for genes affecting the selected response. Hence, other differences between the lines are likely due to pleiotropic actions of those genes. We discuss behavioral pharmacological experiments in two sets of selected lines. Withdrawal Seizure-Prone (WSP) and -Resistant(WSR) mouse lines were selected for severe and minimal handling-induced convulsions (HIC), respectively, after withdrawal from chronic EtOH inhalation. The HIC is also elevated after acute administration of low doses of convulsant drugs. WSP mice were found to be more sensitive than WSR mice to many such drugs. There was no apparent specificity of such effects to any particular neurotransmitter system. Thus, genetic determination of a behavioral response to EtOH in this case cannot be traced to the influence of a single neurotransmitter system. COLD and HOT mice were selectively bred to show severe and mild hypothermia, respectively, after acute EtOH administration. COLD mice are also more sensitive to a number of other alcohols, barbiturates, and other general central nervous system depressants. When tested for sensitivity to a number of drugs with specific effects on neurotransmitter systems, COLD and HOT mice did not differ in sensitivity to drugs affecting dopaminergic, α-adrenergic, or nicotinic acetylcholinergic systems, COLD mice were more sensitive, however, to opioid and serotonergic drugs. Thus, analysis of these selected lines was successful in identifying particular neurotransmitters which may be important in EtOH-induced hypothermia.",
keywords = "COLD/HOT mice, Convulsions, Ethanol, Hypothermia, Pharmacogenetics, Proconvulsant treatments, Selectively bred lines, Withdrawal, WSP/WSR mice",
author = "Crabbe, {John Jr} and Feller, {Daniel J.} and Terdal, {Erik S.} and Merrill, {Catherine D.}",
year = "1990",
doi = "10.1016/0741-8329(90)90013-3",
language = "English (US)",
volume = "7",
pages = "245--248",
journal = "Alcohol",
issn = "0741-8329",
publisher = "Elsevier Inc.",
number = "3",

}

TY - JOUR

T1 - Genetic components of ethanol responses

AU - Crabbe, John Jr

AU - Feller, Daniel J.

AU - Terdal, Erik S.

AU - Merrill, Catherine D.

PY - 1990

Y1 - 1990

N2 - A powerful technique for determining the role of a particular neurotransmitter in mediating a response to ethanol (EtOH) is the analysis of selectively bred lines of animals. Lines selected for sensitivity and resistance to an EtOH effect differ principally in gene frequencies for genes affecting the selected response. Hence, other differences between the lines are likely due to pleiotropic actions of those genes. We discuss behavioral pharmacological experiments in two sets of selected lines. Withdrawal Seizure-Prone (WSP) and -Resistant(WSR) mouse lines were selected for severe and minimal handling-induced convulsions (HIC), respectively, after withdrawal from chronic EtOH inhalation. The HIC is also elevated after acute administration of low doses of convulsant drugs. WSP mice were found to be more sensitive than WSR mice to many such drugs. There was no apparent specificity of such effects to any particular neurotransmitter system. Thus, genetic determination of a behavioral response to EtOH in this case cannot be traced to the influence of a single neurotransmitter system. COLD and HOT mice were selectively bred to show severe and mild hypothermia, respectively, after acute EtOH administration. COLD mice are also more sensitive to a number of other alcohols, barbiturates, and other general central nervous system depressants. When tested for sensitivity to a number of drugs with specific effects on neurotransmitter systems, COLD and HOT mice did not differ in sensitivity to drugs affecting dopaminergic, α-adrenergic, or nicotinic acetylcholinergic systems, COLD mice were more sensitive, however, to opioid and serotonergic drugs. Thus, analysis of these selected lines was successful in identifying particular neurotransmitters which may be important in EtOH-induced hypothermia.

AB - A powerful technique for determining the role of a particular neurotransmitter in mediating a response to ethanol (EtOH) is the analysis of selectively bred lines of animals. Lines selected for sensitivity and resistance to an EtOH effect differ principally in gene frequencies for genes affecting the selected response. Hence, other differences between the lines are likely due to pleiotropic actions of those genes. We discuss behavioral pharmacological experiments in two sets of selected lines. Withdrawal Seizure-Prone (WSP) and -Resistant(WSR) mouse lines were selected for severe and minimal handling-induced convulsions (HIC), respectively, after withdrawal from chronic EtOH inhalation. The HIC is also elevated after acute administration of low doses of convulsant drugs. WSP mice were found to be more sensitive than WSR mice to many such drugs. There was no apparent specificity of such effects to any particular neurotransmitter system. Thus, genetic determination of a behavioral response to EtOH in this case cannot be traced to the influence of a single neurotransmitter system. COLD and HOT mice were selectively bred to show severe and mild hypothermia, respectively, after acute EtOH administration. COLD mice are also more sensitive to a number of other alcohols, barbiturates, and other general central nervous system depressants. When tested for sensitivity to a number of drugs with specific effects on neurotransmitter systems, COLD and HOT mice did not differ in sensitivity to drugs affecting dopaminergic, α-adrenergic, or nicotinic acetylcholinergic systems, COLD mice were more sensitive, however, to opioid and serotonergic drugs. Thus, analysis of these selected lines was successful in identifying particular neurotransmitters which may be important in EtOH-induced hypothermia.

KW - COLD/HOT mice

KW - Convulsions

KW - Ethanol

KW - Hypothermia

KW - Pharmacogenetics

KW - Proconvulsant treatments

KW - Selectively bred lines

KW - Withdrawal

KW - WSP/WSR mice

UR - http://www.scopus.com/inward/record.url?scp=0025071806&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0025071806&partnerID=8YFLogxK

U2 - 10.1016/0741-8329(90)90013-3

DO - 10.1016/0741-8329(90)90013-3

M3 - Article

C2 - 2184836

AN - SCOPUS:0025071806

VL - 7

SP - 245

EP - 248

JO - Alcohol

JF - Alcohol

SN - 0741-8329

IS - 3

ER -