Genetic Architecture of Human Obesity Traits in the Rhesus Macaque

Michael J. Raboin, John Letaw, Asia D. Mitchell, David Toffey, Jessica McKelvey, Charles Roberts, Joanne E. Curran, Amanda Vinson

    Research output: Contribution to journalArticle

    Abstract

    Objective: Whereas the metabolic consequences of obesity have been studied extensively in the rhesus macaque, corollary genetic studies of obesity are nonexistent. This study assessed genetic contributions to spontaneous adiposity in this species. Methods: Phenotypic variation by age class and sex for BMI, waist to height ratio, waist to thigh ratio, and waist circumference was assessed in 583 macaques. Total and sex-specific heritability for all traits was estimated, including waist to thigh ratio adjusted for BMI, as well as genotypic and phenotypic correlations. In addition, functional genetic variation at BDNF, FTO, LEP, LEPR, MC4R, PCSK1, POMC, and SIM1 was assessed in four animals with extreme spontaneous adiposity. Results: Trait heritability in the combined sample was low to moderate (0.14-0.32), whereas sex-specific heritability was more substantial (0.20-0.67). Heritability was greater in females for all traits except BMI. All traits were robustly correlated, with genetic correlations of 0.63 to 0.93 indicating substantial pleiotropy. Likely functional variants were discovered in the four macaques at all eight human obesity genes, including six missense mutations in BDNF, FTO, LEP, LEPR, and PCSK1 and, notably, one nonsense mutation in LEPR. Conclusions: A moderate polygenic contribution to adiposity in rhesus macaques was found, as well as mutations with potentially larger effects in multiple genes that influence obesity in humans.

    Original languageEnglish (US)
    Pages (from-to)479-488
    Number of pages10
    JournalObesity
    Volume27
    Issue number3
    DOIs
    StatePublished - Mar 1 2019

    Fingerprint

    Medical Genetics
    Macaca mulatta
    Adiposity
    Obesity
    Brain-Derived Neurotrophic Factor
    Macaca
    Thigh
    Pro-Opiomelanocortin
    Nonsense Codon
    Waist Circumference
    Missense Mutation
    Genes
    Mutation

    ASJC Scopus subject areas

    • Medicine (miscellaneous)
    • Endocrinology, Diabetes and Metabolism
    • Endocrinology
    • Nutrition and Dietetics

    Cite this

    Raboin, M. J., Letaw, J., Mitchell, A. D., Toffey, D., McKelvey, J., Roberts, C., ... Vinson, A. (2019). Genetic Architecture of Human Obesity Traits in the Rhesus Macaque. Obesity, 27(3), 479-488. https://doi.org/10.1002/oby.22392

    Genetic Architecture of Human Obesity Traits in the Rhesus Macaque. / Raboin, Michael J.; Letaw, John; Mitchell, Asia D.; Toffey, David; McKelvey, Jessica; Roberts, Charles; Curran, Joanne E.; Vinson, Amanda.

    In: Obesity, Vol. 27, No. 3, 01.03.2019, p. 479-488.

    Research output: Contribution to journalArticle

    Raboin, MJ, Letaw, J, Mitchell, AD, Toffey, D, McKelvey, J, Roberts, C, Curran, JE & Vinson, A 2019, 'Genetic Architecture of Human Obesity Traits in the Rhesus Macaque', Obesity, vol. 27, no. 3, pp. 479-488. https://doi.org/10.1002/oby.22392
    Raboin MJ, Letaw J, Mitchell AD, Toffey D, McKelvey J, Roberts C et al. Genetic Architecture of Human Obesity Traits in the Rhesus Macaque. Obesity. 2019 Mar 1;27(3):479-488. https://doi.org/10.1002/oby.22392
    Raboin, Michael J. ; Letaw, John ; Mitchell, Asia D. ; Toffey, David ; McKelvey, Jessica ; Roberts, Charles ; Curran, Joanne E. ; Vinson, Amanda. / Genetic Architecture of Human Obesity Traits in the Rhesus Macaque. In: Obesity. 2019 ; Vol. 27, No. 3. pp. 479-488.
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