Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice

J. E. Foreman, A. Lionikas, D. H. Lang, J. P. Gyekis, M. Krishnan, N. A. Sharkey, G. S. Gerhard, M. D. Grant, G. P. Vogler, H. A. MacK, J. T. Stout, J. W. Griffith, J. M. Lakoski, Scott Hofer, G. E. McClearn, D. J. Vandenbergh, D. A. Blizard

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

A quantitative trait locus (QTL) analysis of behaviors across the life span was conducted in F2 mice from a C57BL/6J × DBA/2J cross and 22 BXD recombinant inbred (RI) strains. Mice of three age groups were tested in a hole-board apparatus for 3 min on three occasions ∼1 month apart (average age at test 150, 450 and 750 days, ∼400 mice per group, divided equally by sex). Quantitative trait loci with small effect size were found on 11 chromosomes for hole-board activity (Hbact) and hole-board rearing (Hbrear). Analysis of 22 RI strains tested at 150 and 450 days of age found only suggestive linkage, with four QTL for Hbact overlapping with those from the F2 analysis. There was a significant phenotypic correlation between Hbact and Hbrear (∼0.55-0.69) and substantial commonality among QTL for the two behaviors. QTL analyses of head-pokes (HP) and fecal boli (FB) only identified QTL at the suggestive level of significance. Age accounted for ∼15% of the phenotypic variance (sex ∼3%), and there were genotype by age interactions at ∼25% of the Hbact and Hbrear QTL. Quantitative trait loci for Hbrear were relatively stable across the three measurement occasions (those for Hbact somewhat less so), although mean levels of each index declined markedly comparing the first to subsequent trials. Considered as a whole, the polygenic system influencing exploratory behaviors accounts for approximately the same amount of phenotypic variance as age (within the range studied), is stable across substantial periods of time, and acts, for the most part, independently of age and sex.

Original languageEnglish (US)
Pages (from-to)714-727
Number of pages14
JournalGenes, Brain and Behavior
Volume8
Issue number7
DOIs
StatePublished - Oct 2009
Externally publishedYes

Fingerprint

Quantitative Trait Loci
Chromosomes, Human, Pair 11
Exploratory Behavior
Inbred C57BL Mouse
Age Groups
Head
Genotype

Keywords

  • Activity
  • Aging
  • Life span
  • QTL
  • Rears
  • Squares

ASJC Scopus subject areas

  • Behavioral Neuroscience
  • Genetics
  • Neurology

Cite this

Foreman, J. E., Lionikas, A., Lang, D. H., Gyekis, J. P., Krishnan, M., Sharkey, N. A., ... Blizard, D. A. (2009). Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. Genes, Brain and Behavior, 8(7), 714-727. https://doi.org/10.1111/j.1601-183X.2009.00516.x

Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. / Foreman, J. E.; Lionikas, A.; Lang, D. H.; Gyekis, J. P.; Krishnan, M.; Sharkey, N. A.; Gerhard, G. S.; Grant, M. D.; Vogler, G. P.; MacK, H. A.; Stout, J. T.; Griffith, J. W.; Lakoski, J. M.; Hofer, Scott; McClearn, G. E.; Vandenbergh, D. J.; Blizard, D. A.

In: Genes, Brain and Behavior, Vol. 8, No. 7, 10.2009, p. 714-727.

Research output: Contribution to journalArticle

Foreman, JE, Lionikas, A, Lang, DH, Gyekis, JP, Krishnan, M, Sharkey, NA, Gerhard, GS, Grant, MD, Vogler, GP, MacK, HA, Stout, JT, Griffith, JW, Lakoski, JM, Hofer, S, McClearn, GE, Vandenbergh, DJ & Blizard, DA 2009, 'Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice', Genes, Brain and Behavior, vol. 8, no. 7, pp. 714-727. https://doi.org/10.1111/j.1601-183X.2009.00516.x
Foreman, J. E. ; Lionikas, A. ; Lang, D. H. ; Gyekis, J. P. ; Krishnan, M. ; Sharkey, N. A. ; Gerhard, G. S. ; Grant, M. D. ; Vogler, G. P. ; MacK, H. A. ; Stout, J. T. ; Griffith, J. W. ; Lakoski, J. M. ; Hofer, Scott ; McClearn, G. E. ; Vandenbergh, D. J. ; Blizard, D. A. / Genetic architecture for hole-board behaviors across substantial time intervals in young, middle-aged and old mice. In: Genes, Brain and Behavior. 2009 ; Vol. 8, No. 7. pp. 714-727.
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