Genetic approaches to drug dependence

John Jr Crabbe, John Belknap

Research output: Contribution to journalArticle

55 Citations (Scopus)

Abstract

Pharmacogenetic studies with drugs of abuse are proliferating. Many genetic animal models are now available for studies of the mechanisms of action of a variety of drugs. These models provide unique, genetically defined populations of extremely sensitive and insensitive animals for neuropharmacological analyses. John Crabbe and John Belknap describe how molecular biological methods are being applied to these models in combination with more traditional genetic mapping strategies to identify single genes of importance to drug effects. Pharmacogenetic approaches offer the hope of establishing commonalities of mechanisms among abused drugs.

Original languageEnglish (US)
Pages (from-to)212-219
Number of pages8
JournalTrends in Pharmacological Sciences
Volume13
Issue numberC
DOIs
StatePublished - 1992

Fingerprint

Substance-Related Disorders
Animals
Pharmaceutical Preparations
Pharmacogenetics
Genetic Models
Street Drugs
Vulnerable Populations
Animal Models
Genes
Pharmacogenomic Testing

ASJC Scopus subject areas

  • Pharmacology
  • Toxicology

Cite this

Genetic approaches to drug dependence. / Crabbe, John Jr; Belknap, John.

In: Trends in Pharmacological Sciences, Vol. 13, No. C, 1992, p. 212-219.

Research output: Contribution to journalArticle

Crabbe, John Jr ; Belknap, John. / Genetic approaches to drug dependence. In: Trends in Pharmacological Sciences. 1992 ; Vol. 13, No. C. pp. 212-219.
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