Abstract
Article abstract-We studied age at onset and family history of 137 patients (probands) with the diagnosis of idiopathic Parkinson's disease (PD). Probands (N = 21) who had an affected parent, aunt, or uncle were younger (p = 0.0001) at the onset of PD (47.7 +\- 8.8 years) than were probands (N = 11) who had an affected sib only (60.3 +\- 12.9 years) and probands (N = 105) who had no affected sib, parent, aunt, or uncle (59.2 +\- 11.4 years). Age at onset of affected family members differed significantly between generations (p = 0.0001). Age at onset was earlier, by an average of 17 years, in the proband generation than in the parental generation. The intrafamily variation in the calendar year of onset was too great to suggest a common point of exposure. Our data are most compatible with genetic anticipation, which could suggest involvement of an unstable trinucleotide repeat.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 135-138 |
| Number of pages | 4 |
| Journal | Neurology |
| Volume | 45 |
| Issue number | 1 |
| State | Published - 1995 |
| Externally published | Yes |
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ASJC Scopus subject areas
- Arts and Humanities (miscellaneous)
- Clinical Neurology
- Neuroscience(all)
Cite this
Genetic anticipation in parkinson's disease. / Payami, H.; Bernard, S.; Larsen, K.; Kaye, Jeffrey; Nutt, John.
In: Neurology, Vol. 45, No. 1, 1995, p. 135-138.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Genetic anticipation in parkinson's disease
AU - Payami, H.
AU - Bernard, S.
AU - Larsen, K.
AU - Kaye, Jeffrey
AU - Nutt, John
PY - 1995
Y1 - 1995
N2 - Article abstract-We studied age at onset and family history of 137 patients (probands) with the diagnosis of idiopathic Parkinson's disease (PD). Probands (N = 21) who had an affected parent, aunt, or uncle were younger (p = 0.0001) at the onset of PD (47.7 +\- 8.8 years) than were probands (N = 11) who had an affected sib only (60.3 +\- 12.9 years) and probands (N = 105) who had no affected sib, parent, aunt, or uncle (59.2 +\- 11.4 years). Age at onset of affected family members differed significantly between generations (p = 0.0001). Age at onset was earlier, by an average of 17 years, in the proband generation than in the parental generation. The intrafamily variation in the calendar year of onset was too great to suggest a common point of exposure. Our data are most compatible with genetic anticipation, which could suggest involvement of an unstable trinucleotide repeat.
AB - Article abstract-We studied age at onset and family history of 137 patients (probands) with the diagnosis of idiopathic Parkinson's disease (PD). Probands (N = 21) who had an affected parent, aunt, or uncle were younger (p = 0.0001) at the onset of PD (47.7 +\- 8.8 years) than were probands (N = 11) who had an affected sib only (60.3 +\- 12.9 years) and probands (N = 105) who had no affected sib, parent, aunt, or uncle (59.2 +\- 11.4 years). Age at onset of affected family members differed significantly between generations (p = 0.0001). Age at onset was earlier, by an average of 17 years, in the proband generation than in the parental generation. The intrafamily variation in the calendar year of onset was too great to suggest a common point of exposure. Our data are most compatible with genetic anticipation, which could suggest involvement of an unstable trinucleotide repeat.
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UR - http://www.scopus.com/inward/citedby.url?scp=0028869758&partnerID=8YFLogxK
M3 - Article
C2 - 7824103
AN - SCOPUS:0028869758
VL - 45
SP - 135
EP - 138
JO - Neurology
JF - Neurology
SN - 0028-3878
IS - 1
ER -