Genetic animal models of alcohol and drug abuse

John Jr Crabbe, John Belknap, Kari Buck

Research output: Contribution to journalArticle

361 Citations (Scopus)

Abstract

Behavioral and pharmacological responses of selectively bred and inbred rodent lines have been analyzed to elucidate many features of drug sensitivity and the adverse effects of drugs, the underlying mechanisms of drug tolerance and dependence, and the motivational states underlying drug reward and aversion. Genetic mapping of quantitative trait loci (QTLs) has been used to identify provisional chromosomal locations of genes influencing such pharmacological responses. Recent advances in transgenic technology, representational difference analysis, and other molecular methods now make feasible the positional cloning of QTLs that influence sensitivity to drugs of abuse. This marks a new period of synthesis in pharmacogenetic research, in which networks of drug-related behaviors, their underlying pharmacological, physiological, and biochemical mechanisms, and particular genomic regions of interest are being identified.

Original languageEnglish (US)
Pages (from-to)1715-1723
Number of pages9
JournalScience
Volume264
Issue number5166
StatePublished - Jun 17 1994

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Genetic Models
Alcoholism
Substance-Related Disorders
Animal Models
Quantitative Trait Loci
Pharmacology
Pharmaceutical Preparations
Drug Tolerance
Pharmacogenetics
Street Drugs
Reward
Organism Cloning
Rodentia
Technology
Research
Genes

ASJC Scopus subject areas

  • General

Cite this

Genetic animal models of alcohol and drug abuse. / Crabbe, John Jr; Belknap, John; Buck, Kari.

In: Science, Vol. 264, No. 5166, 17.06.1994, p. 1715-1723.

Research output: Contribution to journalArticle

Crabbe, JJ, Belknap, J & Buck, K 1994, 'Genetic animal models of alcohol and drug abuse', Science, vol. 264, no. 5166, pp. 1715-1723.
Crabbe JJ, Belknap J, Buck K. Genetic animal models of alcohol and drug abuse. Science. 1994 Jun 17;264(5166):1715-1723.
Crabbe, John Jr ; Belknap, John ; Buck, Kari. / Genetic animal models of alcohol and drug abuse. In: Science. 1994 ; Vol. 264, No. 5166. pp. 1715-1723.
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