Genetic analysis workshop II: Further consideration of segregation and linkage analyses in problem 3

P. L. Kramer, D. B. Altmann, K. K. Kidd

Research output: Contribution to journalArticle


We analyzed disease‐marker associations in Problem 3 for the Genetic Analysis Workshop II, using PAP for segregation analysis and LIPED for linkage analysis. In this report we present aspects of our analyses that are not reported in the summary [MacCluer et al, 1984]. Certain features that we added to the running of LIPED to facilitate the analyses are discussed. Furthermore, we tested for Mendelian transmission in the hypothetical trait locus and we calculated modified relative risks for marker‐trait genotypes. Some of the problems involved in analyzing complex associations among loci are discussed.

Original languageEnglish (US)
Pages (from-to)189-193
Number of pages5
JournalGenetic Epidemiology
Issue number2
StatePublished - 1984



  • linkage analysis
  • segregation analysis

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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