Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men

J. M. Zmuda, L. M. Yerges-Armstrong, S. P. Moffett, L. Klei, C. M. Kammerer, K. Roeder, J. A. Cauley, A. Kuipers, K. E. Ensrud, C. S. Nestlerode, A. R. Hoffman, C. E. Lewis, T. F. Lang, E. Barrett-Connor, R. E. Ferrell, Eric Orwoll

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Summary: We investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone mineral density (vBMD) and cross-sectional area (CSA) in 2,018 Caucasian men aged ≥65 years. SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p

Original languageEnglish (US)
Pages (from-to)1079-1090
Number of pages12
JournalOsteoporosis International
Volume22
Issue number4
DOIs
StatePublished - Apr 2011

Fingerprint

Bone Density
Single Nucleotide Polymorphism
Steroid 11-beta-Hydroxylase
Bone and Bones
Genes
Cancellous Bone
betaglycan

Keywords

  • BMD
  • Genetics
  • Men
  • Osteoporosis
  • Polymorphism
  • QCT

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism

Cite this

Zmuda, J. M., Yerges-Armstrong, L. M., Moffett, S. P., Klei, L., Kammerer, C. M., Roeder, K., ... Orwoll, E. (2011). Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. Osteoporosis International, 22(4), 1079-1090. https://doi.org/10.1007/s00198-010-1296-0

Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. / Zmuda, J. M.; Yerges-Armstrong, L. M.; Moffett, S. P.; Klei, L.; Kammerer, C. M.; Roeder, K.; Cauley, J. A.; Kuipers, A.; Ensrud, K. E.; Nestlerode, C. S.; Hoffman, A. R.; Lewis, C. E.; Lang, T. F.; Barrett-Connor, E.; Ferrell, R. E.; Orwoll, Eric.

In: Osteoporosis International, Vol. 22, No. 4, 04.2011, p. 1079-1090.

Research output: Contribution to journalArticle

Zmuda, JM, Yerges-Armstrong, LM, Moffett, SP, Klei, L, Kammerer, CM, Roeder, K, Cauley, JA, Kuipers, A, Ensrud, KE, Nestlerode, CS, Hoffman, AR, Lewis, CE, Lang, TF, Barrett-Connor, E, Ferrell, RE & Orwoll, E 2011, 'Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men', Osteoporosis International, vol. 22, no. 4, pp. 1079-1090. https://doi.org/10.1007/s00198-010-1296-0
Zmuda JM, Yerges-Armstrong LM, Moffett SP, Klei L, Kammerer CM, Roeder K et al. Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. Osteoporosis International. 2011 Apr;22(4):1079-1090. https://doi.org/10.1007/s00198-010-1296-0
Zmuda, J. M. ; Yerges-Armstrong, L. M. ; Moffett, S. P. ; Klei, L. ; Kammerer, C. M. ; Roeder, K. ; Cauley, J. A. ; Kuipers, A. ; Ensrud, K. E. ; Nestlerode, C. S. ; Hoffman, A. R. ; Lewis, C. E. ; Lang, T. F. ; Barrett-Connor, E. ; Ferrell, R. E. ; Orwoll, Eric. / Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men. In: Osteoporosis International. 2011 ; Vol. 22, No. 4. pp. 1079-1090.
@article{5f7f9e145f0041d19ccd01b8bd3c4d8d,
title = "Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men",
abstract = "Summary: We investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone mineral density (vBMD) and cross-sectional area (CSA) in 2,018 Caucasian men aged ≥65 years. SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p",
keywords = "BMD, Genetics, Men, Osteoporosis, Polymorphism, QCT",
author = "Zmuda, {J. M.} and Yerges-Armstrong, {L. M.} and Moffett, {S. P.} and L. Klei and Kammerer, {C. M.} and K. Roeder and Cauley, {J. A.} and A. Kuipers and Ensrud, {K. E.} and Nestlerode, {C. S.} and Hoffman, {A. R.} and Lewis, {C. E.} and Lang, {T. F.} and E. Barrett-Connor and Ferrell, {R. E.} and Eric Orwoll",
year = "2011",
month = "4",
doi = "10.1007/s00198-010-1296-0",
language = "English (US)",
volume = "22",
pages = "1079--1090",
journal = "Osteoporosis International",
issn = "0937-941X",
publisher = "Springer London",
number = "4",

}

TY - JOUR

T1 - Genetic analysis of vertebral trabecular bone density and cross-sectional area in older men

AU - Zmuda, J. M.

AU - Yerges-Armstrong, L. M.

AU - Moffett, S. P.

AU - Klei, L.

AU - Kammerer, C. M.

AU - Roeder, K.

AU - Cauley, J. A.

AU - Kuipers, A.

AU - Ensrud, K. E.

AU - Nestlerode, C. S.

AU - Hoffman, A. R.

AU - Lewis, C. E.

AU - Lang, T. F.

AU - Barrett-Connor, E.

AU - Ferrell, R. E.

AU - Orwoll, Eric

PY - 2011/4

Y1 - 2011/4

N2 - Summary: We investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone mineral density (vBMD) and cross-sectional area (CSA) in 2,018 Caucasian men aged ≥65 years. SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p

AB - Summary: We investigated 383 bone candidate genes for associations between single nucleotide polymorphisms and vertebral trabecular volumetric bone mineral density (vBMD) and cross-sectional area (CSA) in 2,018 Caucasian men aged ≥65 years. SNPs in TGFBR3, SOST, KL, CALCR, LEP, CSF1R, PTN, GNRH2, FGFR2, and MEPE were associated with vBMD and SNPs in CYP11B1, DVL2, DLX5, WNT4, and PAX7 were associated with CSA in independent study samples (p

KW - BMD

KW - Genetics

KW - Men

KW - Osteoporosis

KW - Polymorphism

KW - QCT

UR - http://www.scopus.com/inward/record.url?scp=79953297925&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79953297925&partnerID=8YFLogxK

U2 - 10.1007/s00198-010-1296-0

DO - 10.1007/s00198-010-1296-0

M3 - Article

VL - 22

SP - 1079

EP - 1090

JO - Osteoporosis International

JF - Osteoporosis International

SN - 0937-941X

IS - 4

ER -