TY - JOUR
T1 - Genetic analysis of a Chinese hamster cell line lacking a G1 phase
AU - Liskay, R. Michael
N1 - Funding Information:
The author would like to thank Dr David M. Prescott for his useful discussionsc oncerningt his work. Also appreciateda re commentso n the manuscriptb y Drs D. M. Prescott, G. Herrick, G. Stein, and S. Gartler. This work was supportedb y an ACS grant (VC-193) to D. M. Prescott and Postdoctoral Fellowships to R. M. Liskay from the Damon Runyon-Walter Win-chell Cancer Fund (DRG-33-F) and the NC1 of the NIH (5 F32 CA 05203).
PY - 1978/6
Y1 - 1978/6
N2 - A Chinese hamster cell line (V79-8), which lacks a measurable G1 phase in its cell cycle (G1-), has been investigated utilizing somatic cell hybrids. The results indicate that the G1- phenotype is dominant in two types of intraspecific hybrids and, surprisingly is in contrast recessive in two different interspecific crosses. Furthermore, the G1- V79-8 cell line complements two different G1 defective cell cycle mutants, suggesting that V79-8 retains and can express at least some G1-specific functions.
AB - A Chinese hamster cell line (V79-8), which lacks a measurable G1 phase in its cell cycle (G1-), has been investigated utilizing somatic cell hybrids. The results indicate that the G1- phenotype is dominant in two types of intraspecific hybrids and, surprisingly is in contrast recessive in two different interspecific crosses. Furthermore, the G1- V79-8 cell line complements two different G1 defective cell cycle mutants, suggesting that V79-8 retains and can express at least some G1-specific functions.
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U2 - 10.1016/0014-4827(78)90037-X
DO - 10.1016/0014-4827(78)90037-X
M3 - Article
C2 - 658159
AN - SCOPUS:0018100085
SN - 0014-4827
VL - 114
SP - 69
EP - 77
JO - Experimental Cell Research
JF - Experimental Cell Research
IS - 1
ER -