A Chinese hamster cell line (V79-8), which lacks a measurable G1 phase in its cell cycle (G1-), has been investigated utilizing somatic cell hybrids. The results indicate that the G1- phenotype is dominant in two types of intraspecific hybrids and, surprisingly is in contrast recessive in two different interspecific crosses. Furthermore, the G1- V79-8 cell line complements two different G1 defective cell cycle mutants, suggesting that V79-8 retains and can express at least some G1-specific functions.
ASJC Scopus subject areas
- Cell Biology