Genetic alterations and histopathologic findings in familial renal cell carcinoma

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Renal cell carcinoma is increasing in frequency in the United States and is often detected late in the course of disease due to nonspecific symptoms. A subset of renal cell carcinoma is attributable to familial or hereditary syndromes, including von Hippel-Lindau and Birt-Hogg-Dubé syndromes, among others. Understanding of the molecular alterations in patients with familial syndromes may provide some insight into the underlying mechanisms of disease initiation and progression. This review describes the various subtypes of renal cell carcinoma and the familial syndromes associated with these tumors.

Original languageEnglish (US)
Pages (from-to)437-444
Number of pages8
JournalHistology and histopathology
Volume21
Issue number4-6
StatePublished - Apr 2006
Externally publishedYes

Keywords

  • Kidney
  • Kidney cancer
  • Neoplasia
  • Pathology
  • Review

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Histology

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