Generation of activated protein C during thrombolysis

Andras Gruber, J. H. Griffin, A. Pál, G. Sas, R. G. Kiss

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

Original languageEnglish (US)
Pages (from-to)1275-1276
Number of pages2
JournalThe Lancet
Volume342
Issue number8882
DOIs
StatePublished - Nov 20 1993
Externally publishedYes

Fingerprint

Protein C
Thrombolytic Therapy
Streptokinase
Papio
Fibrinolysin
Urokinase-Type Plasminogen Activator
Enzymes
Anticoagulants

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Gruber, A., Griffin, J. H., Pál, A., Sas, G., & Kiss, R. G. (1993). Generation of activated protein C during thrombolysis. The Lancet, 342(8882), 1275-1276. https://doi.org/10.1016/0140-6736(93)92364-Y

Generation of activated protein C during thrombolysis. / Gruber, Andras; Griffin, J. H.; Pál, A.; Sas, G.; Kiss, R. G.

In: The Lancet, Vol. 342, No. 8882, 20.11.1993, p. 1275-1276.

Research output: Contribution to journalArticle

Gruber, A, Griffin, JH, Pál, A, Sas, G & Kiss, RG 1993, 'Generation of activated protein C during thrombolysis', The Lancet, vol. 342, no. 8882, pp. 1275-1276. https://doi.org/10.1016/0140-6736(93)92364-Y
Gruber, Andras ; Griffin, J. H. ; Pál, A. ; Sas, G. ; Kiss, R. G. / Generation of activated protein C during thrombolysis. In: The Lancet. 1993 ; Vol. 342, No. 8882. pp. 1275-1276.
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