Generation of activated protein C during thrombolysis

A. Gruber, J. H. Griffin, A. Pál, G. Sas, R. G. Kiss

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27 Scopus citations


The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

Original languageEnglish (US)
Pages (from-to)1275-1276
Number of pages2
JournalThe Lancet
Issue number8882
StatePublished - Nov 20 1993

ASJC Scopus subject areas

  • Medicine(all)

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    Gruber, A., Griffin, J. H., Pál, A., Sas, G., & Kiss, R. G. (1993). Generation of activated protein C during thrombolysis. The Lancet, 342(8882), 1275-1276.