Generation of activated protein C during thrombolysis

A. Gruber; J. H. Griffin; A. Pál; G. Sas; R. G. Kiss

doi:10.1016/0140-6736(93)92364-Y

Generation of activated protein C during thrombolysis

A. Gruber, J. H. Griffin, A. Pál, G. Sas, R. G. Kiss

Research output: Contribution to journal › Article › peer-review

28 Scopus citations

Abstract

The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

Original language	English (US)
Pages (from-to)	1275-1276
Number of pages	2
Journal	The Lancet
Volume	342
Issue number	8882
DOIs	https://doi.org/10.1016/0140-6736(93)92364-Y
State	Published - Nov 20 1993
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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10.1016/0140-6736(93)92364-Y

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@article{a7851ec83fde40449fd9e23bcdbf4110,

title = "Generation of activated protein C during thrombolysis",

abstract = "The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.",

author = "A. Gruber and Griffin, {J. H.} and A. P{\'a}l and G. Sas and Kiss, {R. G.}",

note = "Funding Information: This study was supported in part by NIH grant HL-31950, California Tobacco Related Disease Program grants 2RT 0342 and 1RT 304, and the Sam and Rose Stein Trust Fund.",

year = "1993",

month = nov,

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doi = "10.1016/0140-6736(93)92364-Y",

language = "English (US)",

volume = "342",

pages = "1275--1276",

journal = "The Lancet",

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TY - JOUR

T1 - Generation of activated protein C during thrombolysis

AU - Gruber, A.

AU - Griffin, J. H.

AU - Pál, A.

AU - Sas, G.

AU - Kiss, R. G.

N1 - Funding Information: This study was supported in part by NIH grant HL-31950, California Tobacco Related Disease Program grants 2RT 0342 and 1RT 304, and the Sam and Rose Stein Trust Fund.

PY - 1993/11/20

Y1 - 1993/11/20

N2 - The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

AB - The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

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DO - 10.1016/0140-6736(93)92364-Y

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AN - SCOPUS:0027444776

SN - 0140-6736

VL - 342

SP - 1275

EP - 1276

JO - The Lancet

JF - The Lancet

IS - 8882

ER -

Generation of activated protein C during thrombolysis

Abstract

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