Generation of activated protein C during thrombolysis

A. Gruber, J. H. Griffin, A. Pál, G. Sas, R. G. Kiss

Research output: Contribution to journalArticle

27 Scopus citations

Abstract

The observation that urokinase infusion increases circulating levels of the anticoagulant activated protein C (APC) in baboons implies that APC might be elevated during thrombolytic therapy. Patients undergoing coronary thrombolysis showed an 11-fold increase (means from 6 to 69 μg/L) in APC during infusion of streptokinase. Thrombolytic therapy thus generates at least two potent antithrombotic factors in the circulation-the fibrinolytic enzyme, plasmin, and the anticoagulant enzyme, APC. APC may help prevent reocclusion during or after thrombolysis.

Original languageEnglish (US)
Pages (from-to)1275-1276
Number of pages2
JournalThe Lancet
Volume342
Issue number8882
DOIs
StatePublished - Nov 20 1993

ASJC Scopus subject areas

  • Medicine(all)

Fingerprint Dive into the research topics of 'Generation of activated protein C during thrombolysis'. Together they form a unique fingerprint.

  • Cite this

    Gruber, A., Griffin, J. H., Pál, A., Sas, G., & Kiss, R. G. (1993). Generation of activated protein C during thrombolysis. The Lancet, 342(8882), 1275-1276. https://doi.org/10.1016/0140-6736(93)92364-Y