Abstract
Gene regulatory networks underlie biological function and cellular physiology. Alternative splicing (AS) is a fundamental step in gene regulatory networks and plays a key role in development and disease. In addition to the identification of aberrant AS events, an increasing number of studies are focusing on molecular determinants of AS, including genetic and epigenetic regulators. We review here recent efforts to identify various deregulated AS events as well as their molecular determinants that alter biological functions, and discuss clinical features of AS and their druggable potential.
Original language | English (US) |
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Pages (from-to) | 576-592 |
Number of pages | 17 |
Journal | Trends in Biochemical Sciences |
Volume | 43 |
Issue number | 8 |
DOIs | |
State | Published - Aug 2018 |
Externally published | Yes |
Keywords
- alternative splicing
- computational and experimental methods
- gene regulatory networks
- genetic and epigenetic
- molecular regulators
ASJC Scopus subject areas
- Biochemistry
- Molecular Biology