Gene regulation by song in the auditory telencephalon of songbirds

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Inducible gene expression analysis has been successfully used to identify and characterize areas involved in the auditory processing of song in songbirds. When songbirds hear song, zenk, a gene encoding a transcriptional regulator linked to synaptic plasticity, is rapidly and transiently induced in several discrete areas of the telencephalon. This phenomenon is most marked in the caudomedial neostriatum (NCM), a major auditory processing area. zenk induction by song has proven very useful to investigate the functional organization of NCM as well as to characterize song-responding neurons in this brain area. Combined with data from anatomical and electrophysiological studies, the results of gene expression analysis suggest that NCM is involved in the auditory processing of complex sounds such as song and possibly in the formation and/or storage of song auditory memories. Thus, NCM appears to play a prominent role in perceptual aspects of vocal communication, and potentially in the process of vocal learning in songbirds and other vocal learning avian orders, i.e. parrots and hummingbirds.

Original languageEnglish (US)
Pages (from-to)63-73
Number of pages11
JournalFrontiers in bioscience : a journal and virtual library
Volume9
StatePublished - 2004

Fingerprint

Telencephalon
Songbirds
Music
Gene expression
Processing
Genes
Gene encoding
Neurons
Plasticity
Brain
Acoustic waves
Learning
Parrots
Neostriatum
Gene Expression
Data storage equipment
Auditory Cortex
Neuronal Plasticity
Communication

Keywords

  • Auditory
  • Birdsong
  • Canary
  • egr-1
  • Immunocytochemistry
  • In Situ Hybridization
  • Learning
  • Neuronal Plasticity
  • Review
  • Zebra Finch
  • zenk
  • zif-268

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Biochemistry
  • Cell Biology

Cite this

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title = "Gene regulation by song in the auditory telencephalon of songbirds",
abstract = "Inducible gene expression analysis has been successfully used to identify and characterize areas involved in the auditory processing of song in songbirds. When songbirds hear song, zenk, a gene encoding a transcriptional regulator linked to synaptic plasticity, is rapidly and transiently induced in several discrete areas of the telencephalon. This phenomenon is most marked in the caudomedial neostriatum (NCM), a major auditory processing area. zenk induction by song has proven very useful to investigate the functional organization of NCM as well as to characterize song-responding neurons in this brain area. Combined with data from anatomical and electrophysiological studies, the results of gene expression analysis suggest that NCM is involved in the auditory processing of complex sounds such as song and possibly in the formation and/or storage of song auditory memories. Thus, NCM appears to play a prominent role in perceptual aspects of vocal communication, and potentially in the process of vocal learning in songbirds and other vocal learning avian orders, i.e. parrots and hummingbirds.",
keywords = "Auditory, Birdsong, Canary, egr-1, Immunocytochemistry, In Situ Hybridization, Learning, Neuronal Plasticity, Review, Zebra Finch, zenk, zif-268",
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AB - Inducible gene expression analysis has been successfully used to identify and characterize areas involved in the auditory processing of song in songbirds. When songbirds hear song, zenk, a gene encoding a transcriptional regulator linked to synaptic plasticity, is rapidly and transiently induced in several discrete areas of the telencephalon. This phenomenon is most marked in the caudomedial neostriatum (NCM), a major auditory processing area. zenk induction by song has proven very useful to investigate the functional organization of NCM as well as to characterize song-responding neurons in this brain area. Combined with data from anatomical and electrophysiological studies, the results of gene expression analysis suggest that NCM is involved in the auditory processing of complex sounds such as song and possibly in the formation and/or storage of song auditory memories. Thus, NCM appears to play a prominent role in perceptual aspects of vocal communication, and potentially in the process of vocal learning in songbirds and other vocal learning avian orders, i.e. parrots and hummingbirds.

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