Gene Expression Profiling of Renal Medullary Carcinoma

Potential Clinical Relevance

Ximing J. Yang, Jun Sugimura, Maria S. Tretiakova, Kyle Furge, Gregory Zagaja, Mitchell Sokoloff, Michael Pins, Raymond Bergan, David J. Grignon, Walter M. Stadler, Nicholas J. Vogelzang, Bin Tean Teh

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

BACKGROUND. Renal medullary carcinoma is a rare kidney tumor with highly aggressive behavior. This tumor occurs exclusively in young patients with sickle cell trait or disease. To the authors' knowledge, very little is known to date regarding the underlying molecular genetics of this tumor, and no effective therapy has been established. METHODS. The authors analyzed the gene expression profiles of 2 renal medullary carcinomas from patients with sickle cell trait using microarrays containing 21,632 cyclic DNA (cDNA) clones and compared them with the gene expression profiles of 64 renal tumors. RESULTS. Based on global gene clustering with 3583 selected cDNAs, the authors found a distinct molecular signature of renal medullary carcinoma, which clustered closely with urothelial (transitional cell) carcinoma of the renal pelvis, rather than renal cell carcinoma (RCC). This finding of a significant difference in the gene expression patterns of renal medullary carcinoma compared with RCC suggests that this tumor should not be treated as a conventional RCC but, rather, as a special malignancy. This study also identified genes/proteins that may serve as biomarkers for renal medullary carcinoma or as potential targets of novel therapies. In addition, comparative genomic microarray analysis allowed the authors to predict the lack of chromosomal imbalances in this tumor. CONCLUSIONS. To the authors' knowledge, the current study is the first molecular profiling of renal medullary carcinoma, a rare but highly aggressive kidney carcinoma. The genes that are expressed specifically in this tumor may lead to not only a better understanding of its molecular pathways and discoveries of novel diagnostic markers but also, more important, to effective therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)976-985
Number of pages10
JournalCancer
Volume100
Issue number5
DOIs
StatePublished - Mar 1 2004
Externally publishedYes

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Medullary Carcinoma
Gene Expression Profiling
Kidney
Neoplasms
Renal Cell Carcinoma
Sickle Cell Trait
Transcriptome
Kidney Pelvis
Transitional Cell Carcinoma
Sickle Cell Anemia
Microarray Analysis
Genes
Cluster Analysis
Molecular Biology
Therapeutics
Complementary DNA
Clone Cells
Biomarkers
Carcinoma
Gene Expression

Keywords

  • Medullary carcinoma
  • Microarray
  • Molecular biology
  • Renal carcinoma
  • Sickle cell

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Yang, X. J., Sugimura, J., Tretiakova, M. S., Furge, K., Zagaja, G., Sokoloff, M., ... Teh, B. T. (2004). Gene Expression Profiling of Renal Medullary Carcinoma: Potential Clinical Relevance. Cancer, 100(5), 976-985. https://doi.org/10.1002/cncr.20049

Gene Expression Profiling of Renal Medullary Carcinoma : Potential Clinical Relevance. / Yang, Ximing J.; Sugimura, Jun; Tretiakova, Maria S.; Furge, Kyle; Zagaja, Gregory; Sokoloff, Mitchell; Pins, Michael; Bergan, Raymond; Grignon, David J.; Stadler, Walter M.; Vogelzang, Nicholas J.; Teh, Bin Tean.

In: Cancer, Vol. 100, No. 5, 01.03.2004, p. 976-985.

Research output: Contribution to journalArticle

Yang, XJ, Sugimura, J, Tretiakova, MS, Furge, K, Zagaja, G, Sokoloff, M, Pins, M, Bergan, R, Grignon, DJ, Stadler, WM, Vogelzang, NJ & Teh, BT 2004, 'Gene Expression Profiling of Renal Medullary Carcinoma: Potential Clinical Relevance', Cancer, vol. 100, no. 5, pp. 976-985. https://doi.org/10.1002/cncr.20049
Yang XJ, Sugimura J, Tretiakova MS, Furge K, Zagaja G, Sokoloff M et al. Gene Expression Profiling of Renal Medullary Carcinoma: Potential Clinical Relevance. Cancer. 2004 Mar 1;100(5):976-985. https://doi.org/10.1002/cncr.20049
Yang, Ximing J. ; Sugimura, Jun ; Tretiakova, Maria S. ; Furge, Kyle ; Zagaja, Gregory ; Sokoloff, Mitchell ; Pins, Michael ; Bergan, Raymond ; Grignon, David J. ; Stadler, Walter M. ; Vogelzang, Nicholas J. ; Teh, Bin Tean. / Gene Expression Profiling of Renal Medullary Carcinoma : Potential Clinical Relevance. In: Cancer. 2004 ; Vol. 100, No. 5. pp. 976-985.
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abstract = "BACKGROUND. Renal medullary carcinoma is a rare kidney tumor with highly aggressive behavior. This tumor occurs exclusively in young patients with sickle cell trait or disease. To the authors' knowledge, very little is known to date regarding the underlying molecular genetics of this tumor, and no effective therapy has been established. METHODS. The authors analyzed the gene expression profiles of 2 renal medullary carcinomas from patients with sickle cell trait using microarrays containing 21,632 cyclic DNA (cDNA) clones and compared them with the gene expression profiles of 64 renal tumors. RESULTS. Based on global gene clustering with 3583 selected cDNAs, the authors found a distinct molecular signature of renal medullary carcinoma, which clustered closely with urothelial (transitional cell) carcinoma of the renal pelvis, rather than renal cell carcinoma (RCC). This finding of a significant difference in the gene expression patterns of renal medullary carcinoma compared with RCC suggests that this tumor should not be treated as a conventional RCC but, rather, as a special malignancy. This study also identified genes/proteins that may serve as biomarkers for renal medullary carcinoma or as potential targets of novel therapies. In addition, comparative genomic microarray analysis allowed the authors to predict the lack of chromosomal imbalances in this tumor. CONCLUSIONS. To the authors' knowledge, the current study is the first molecular profiling of renal medullary carcinoma, a rare but highly aggressive kidney carcinoma. The genes that are expressed specifically in this tumor may lead to not only a better understanding of its molecular pathways and discoveries of novel diagnostic markers but also, more important, to effective therapeutic interventions.",
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