Gene expression induced by drugs of abuse

Justin S. Rhodes, John Jr Crabbe

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

The transition from infrequent drug use to addiction (i.e. the loss of control over consumption of a drug) probably involves changes in gene expression that restructure neural circuits in the brain. The number of genes that have been demonstrated to change expression in response to drugs has increased rapidly in recent years owing to microarray technology, which allows measurement of thousands of genes at one time. It is now important to identify which of these changes are causally related to the compulsive behavior associated with drug addiction, and which are non-specific changes related to general features of arousal or other physiological responses (e.g. stress, altered body temperature or energy metabolism).

Original languageEnglish (US)
Pages (from-to)26-33
Number of pages8
JournalCurrent Opinion in Pharmacology
Volume5
Issue number1
DOIs
StatePublished - Feb 2005
Externally publishedYes

Fingerprint

Street Drugs
Gene Expression
Pharmaceutical Preparations
Compulsive Behavior
Physiological Stress
Arousal
Body Temperature
Energy Metabolism
Genes
Substance-Related Disorders
Technology
Brain

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Gene expression induced by drugs of abuse. / Rhodes, Justin S.; Crabbe, John Jr.

In: Current Opinion in Pharmacology, Vol. 5, No. 1, 02.2005, p. 26-33.

Research output: Contribution to journalArticle

Rhodes, Justin S. ; Crabbe, John Jr. / Gene expression induced by drugs of abuse. In: Current Opinion in Pharmacology. 2005 ; Vol. 5, No. 1. pp. 26-33.
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