Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

Nisha Anand, Sabita Murthy, Gudrun Amann, Meredith Wernick, Lisa A. Porter, I. Howard Cukier, Colin Collins, Joe Gray, Joachim Diebold, Doug J. Demetrick, Jonathan M. Lee

Research output: Contribution to journalArticle

188 Citations (Scopus)

Abstract

We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1α2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalNature Genetics
Volume31
Issue number3
DOIs
StatePublished - Jul 2002
Externally publishedYes

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Peptide Elongation Factors
Oncogenes
Ovarian Neoplasms
Fibroblasts
Growth
Tumor Cell Line
Nude Mice
Rodentia
Proteins
Carcinoma
Neoplasms

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)

Cite this

Anand, N., Murthy, S., Amann, G., Wernick, M., Porter, L. A., Cukier, I. H., ... Lee, J. M. (2002). Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nature Genetics, 31(3), 301-305. https://doi.org/10.1038/ng904

Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. / Anand, Nisha; Murthy, Sabita; Amann, Gudrun; Wernick, Meredith; Porter, Lisa A.; Cukier, I. Howard; Collins, Colin; Gray, Joe; Diebold, Joachim; Demetrick, Doug J.; Lee, Jonathan M.

In: Nature Genetics, Vol. 31, No. 3, 07.2002, p. 301-305.

Research output: Contribution to journalArticle

Anand, N, Murthy, S, Amann, G, Wernick, M, Porter, LA, Cukier, IH, Collins, C, Gray, J, Diebold, J, Demetrick, DJ & Lee, JM 2002, 'Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer', Nature Genetics, vol. 31, no. 3, pp. 301-305. https://doi.org/10.1038/ng904
Anand N, Murthy S, Amann G, Wernick M, Porter LA, Cukier IH et al. Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nature Genetics. 2002 Jul;31(3):301-305. https://doi.org/10.1038/ng904
Anand, Nisha ; Murthy, Sabita ; Amann, Gudrun ; Wernick, Meredith ; Porter, Lisa A. ; Cukier, I. Howard ; Collins, Colin ; Gray, Joe ; Diebold, Joachim ; Demetrick, Doug J. ; Lee, Jonathan M. / Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. In: Nature Genetics. 2002 ; Vol. 31, No. 3. pp. 301-305.
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