Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer

Nisha Anand, Sabita Murthy, Gudrun Amann, Meredith Wernick, Lisa A. Porter, I. Howard Cukier, Colin Collins, Joe W. Gray, Joachim Diebold, Doug J. Demetrick, Jonathan M. Lee

Research output: Contribution to journalArticle

193 Scopus citations

Abstract

We have found that EEF1A2, the gene encoding protein elongation factor EEF1A2 (also known as eEF-1α2), is amplified in 25% of primary ovarian tumors and is highly expressed in approximately 30% of ovarian tumors and established cell lines. We have also demonstrated that EEF1A2 has oncogenic properties: it enhances focus formation, allows anchorage-independent growth and decreases the doubling time of rodent fibroblasts. In addition, EEF1A2 expression made NIH3T3 fibroblasts tumorigenic and increased the growth rate of ES-2 ovarian carcinoma cells xenografted in nude mice. Thus, EEF1A2 and the process of protein elongation are likely to be critical in the development of ovarian cancer.

Original languageEnglish (US)
Pages (from-to)301-305
Number of pages5
JournalNature genetics
Volume31
Issue number3
DOIs
StatePublished - Jul 2002

ASJC Scopus subject areas

  • Genetics

Fingerprint Dive into the research topics of 'Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer'. Together they form a unique fingerprint.

  • Cite this

    Anand, N., Murthy, S., Amann, G., Wernick, M., Porter, L. A., Cukier, I. H., Collins, C., Gray, J. W., Diebold, J., Demetrick, D. J., & Lee, J. M. (2002). Gene encoding protein elongation factor EEF1A2 is a putative oncogene in ovarian cancer. Nature genetics, 31(3), 301-305. https://doi.org/10.1038/ng904