@article{b968296063384ccaa24992a18a17f2b0,
title = "Gene-by-Environment Interaction Effects of Social Adversity on Externalizing Behavior in ABCD Youth",
abstract = "This study tested whether multiple domains of social adversity, including neighborhood opportunity/deprivation and life stress, moderate genetic (A), common environmental (C), and unique environmental (E) influences on externalizing behaviors in 760 same-sex twin pairs (332 monozygotic; 428 dizygotic) ages 10–11 from the ABCD Study. Proportion of C influences on externalizing behavior increased at higher neighborhood adversity (lower overall opportunity). A decreased and C and E increased at lower levels of educational opportunity. A increased at lower health-environment and social-economic opportunity levels. For life stress, A decreased and E increased with number of experienced events. Results for educational opportunity and stressful life experiences suggest a bioecological gene-environment interaction pattern such that environmental influences predominate at higher levels of adversity, whereas limited access to healthcare, housing, and employment stability may potentiate genetic liability for externalizing behavior via a diathesis-stress mechanism. More detailed operationalization of social adversity in gene-environment interaction studies is needed.",
keywords = "ABCD, Externalizing, Gene-environment interaction, Life stress, Social adversity, Twin study",
author = "Dash, {Genevieve F.} and Sarah Karalunas and Kenyon, {Emily A.} and Carter, {Emily K.} and Michael Mooney and Nigg, {Joel T.} and {Feldstein Ewing}, Sarah",
note = "Funding Information: This research was supported by the National Institute on Drug Abuse grant numbers F31DA054701 (PI: Dash) and U01DA041148-01 (MPIs: Nagel, Feldstein Ewing, Fair), the National Institute on Alcohol Abuse and Alcoholism grant number K24AA026876-01 (PI: Feldstein Ewing), and the National Institute on Mental Health grant number R37MH059105 (PI: Nigg). Data used in the preparation of this article were obtained from the Adolescent Brain Cognitive Development(ABCD) Study ( https://abcdstudy.org ), held in the NIMH Data Archive (NDA). This is a multisite, longitudinal study designed to recruit more than 10,000 children age 9–10 and follow them over 10 years into early adulthood. The ABCD Study{\textregistered} is supported by the National Institutes of Health and additional federal partners under award numbers U01DA041048, U01DA050989, U01DA051016, U01DA041022, U01DA051018, U01DA051037, U01DA050987, U01DA041174, U01DA041106, U01DA041117, U01DA041028, U01DA041134, U01DA050988, U01DA051039, U01DA041156, U01DA041025, U01DA041120, U01DA051038, U01DA041148, U01DA041093, U01DA041089, U24DA041123, U24DA041147. A full list of supporters is available at https://abcdstudy.org/federal-partners.html . A listing of participating sites and a complete listing of the study investigators can be found at https://abcdstudy.org/consortium_members/ . ABCD consortium investigators designed and implemented the study and/or provided data but did not necessarily participate in the analysis or writing of this report. This manuscript reflects the views of the authors and may not reflect the opinions or views of the NIH or ABCD consortium investigators. SM Publisher Copyright: {\textcopyright} 2023, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2023",
doi = "10.1007/s10519-023-10136-z",
language = "English (US)",
journal = "Behavior Genetics",
issn = "0001-8244",
publisher = "Springer New York",
}