Gender-specific physical symptom biology in heart failure

Christopher Lee, Shirin O. Hiatt, Quin Denfeld, Christopher Chien, James Mudd, Jill Gelow

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: There are several gender differences that may help explain the link between biology and symptoms in heart failure (HF). Objective: The aim of this study was to examine gender-specific relationships between objective measures of HF severity and physical symptoms. Methods: Detailed clinical data, including left ventricular ejection fraction and left ventricular internal end-diastolic diameter, and HF-specific physical symptoms were collected as part of a prospective cohort study. Gender interaction terms were tested in linear regression models of physical symptoms. Results: The sample (101 women and 101 men) averaged 57 years of age and most participants (60%) had class III/IV HF. Larger left ventricle size was associated with better physical symptoms for women and worse physical symptoms for men. Conclusion: Decreased ventricular compliance may result in worse physical HF symptoms for women and dilation of the ventricle may be a greater progenitor of symptoms for men with HF.

Original languageEnglish (US)
Pages (from-to)517-521
Number of pages5
JournalJournal of Cardiovascular Nursing
Volume30
Issue number6
DOIs
StatePublished - Oct 9 2015

Fingerprint

Heart Failure
Linear Models
Diastolic Heart Failure
Stroke Volume
Compliance
Heart Ventricles
Dilatation
Cohort Studies
Prospective Studies

Keywords

  • Gender
  • Heart Failure
  • Symptoms

ASJC Scopus subject areas

  • Advanced and Specialized Nursing
  • Cardiology and Cardiovascular Medicine

Cite this

Gender-specific physical symptom biology in heart failure. / Lee, Christopher; Hiatt, Shirin O.; Denfeld, Quin; Chien, Christopher; Mudd, James; Gelow, Jill.

In: Journal of Cardiovascular Nursing, Vol. 30, No. 6, 09.10.2015, p. 517-521.

Research output: Contribution to journalArticle

Lee, Christopher ; Hiatt, Shirin O. ; Denfeld, Quin ; Chien, Christopher ; Mudd, James ; Gelow, Jill. / Gender-specific physical symptom biology in heart failure. In: Journal of Cardiovascular Nursing. 2015 ; Vol. 30, No. 6. pp. 517-521.
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