We used the adoptive transfer model of EAE to elucidate the role of gender on the induction and effector phases of disease. Proteolipid protein peptide 139-151 (PLP 139-151) sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However there were no gender differences in the frequency of PLP 139-151 specific T cells. PLP 139-151 specific T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase. Female T cell lines secreted significantly more IFN-γ and less IL-10 than male cells, suggesting that differences in the severity of clinical disease are related, at least in part, to differences in cytokine production.
|Original language||English (US)|
|State||Published - Mar 20 1998|
ASJC Scopus subject areas
- Molecular Biology