Gender differences in T cell cytokine secretion and the adoptive transfer of Experimental Autoimmune Encephalomyelitis (EAE)

B. F. Bebo, J. C. Schuster, A. A. Vandenbark, H. Offner

Research output: Contribution to journalArticlepeer-review

Abstract

We used the adoptive transfer model of EAE to elucidate the role of gender on the induction and effector phases of disease. Proteolipid protein peptide 139-151 (PLP 139-151) sensitized spleen cells from female SJL mice were more effective at transferring disease than male cells. However there were no gender differences in the frequency of PLP 139-151 specific T cells. PLP 139-151 specific T cell lines induced more severe disease than male T cell lines. Disease severity was more strongly linked to the sex of the donor T cells, indicating that gender influences the immune response primarily during the induction phase. Female T cell lines secreted significantly more IFN-γ and less IL-10 than male cells, suggesting that differences in the severity of clinical disease are related, at least in part, to differences in cytokine production.

Original languageEnglish (US)
Pages (from-to)A1100
JournalFASEB Journal
Volume12
Issue number5
StatePublished - Mar 20 1998

ASJC Scopus subject areas

  • Biotechnology
  • Biochemistry
  • Molecular Biology
  • Genetics

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