Gender difference in airway hyperresponsiveness in smokers with mild COPD

The lung health study

Richard E. Kanner, John E. Connett, Murray D. Altose, A (Sonia) Buist, Wondra W. Lee, Donald P. Tashkin, Robert A. Wise

Research output: Contribution to journalArticle

181 Citations (Scopus)

Abstract

Methacholine bronchoprovocation challenge testing was successfully completed in 5,662 participants (3,556 men and 2,106 women) at the time they were randomized into the Lung Health Study, a multicenter trial designed to evaluate early intervention in chronic obstructive pulmonary disease (COPD). All participants were smokers between the ages of 35 and 60 yr who had mild COPD. The male:female prevalence of a positive challenge (PC20FEV1) was 25%:48% and 63%:87% at a PC20FEV1 of ≤ 5 mg/ml (AHR5) and ≤ 25 mg/ml (AHR25), respectively. This analysis explores these marked gender differences in airway hyperresponsiveness (AHR). Relative risks (RR) for predictors of AHR and the 95% confidence intervals (95% CI) were estimated using semiparametric Cox proportional-hazards models. The initial model controlled for age, gender, smoking history, height, and weight. The RR (95% CI) for female gender was 1.75 (1.60, 1.92). When the measured baseline FEV1 was added to the model as a surrogate for airway caliber, the RR for female gender decreased to 1.06 (0.96, 1.18). Thus, in this population of middle- aged smokers with mild COPD, the high prevalence of AHR appears to be associated with a decrease in airway caliber. The higher prevalence of AHR noted in women is due to their having a smaller airway caliber than their male counterparts.

Original languageEnglish (US)
Pages (from-to)956-961
Number of pages6
JournalAmerican Journal of Respiratory and Critical Care Medicine
Volume150
Issue number4
StatePublished - Oct 1994
Externally publishedYes

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Chronic Obstructive Pulmonary Disease
Lung
Health
Confidence Intervals
Methacholine Chloride
Proportional Hazards Models
Multicenter Studies
Smoking
History
Weights and Measures
Population

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Kanner, R. E., Connett, J. E., Altose, M. D., Buist, A. S., Lee, W. W., Tashkin, D. P., & Wise, R. A. (1994). Gender difference in airway hyperresponsiveness in smokers with mild COPD: The lung health study. American Journal of Respiratory and Critical Care Medicine, 150(4), 956-961.

Gender difference in airway hyperresponsiveness in smokers with mild COPD : The lung health study. / Kanner, Richard E.; Connett, John E.; Altose, Murray D.; Buist, A (Sonia); Lee, Wondra W.; Tashkin, Donald P.; Wise, Robert A.

In: American Journal of Respiratory and Critical Care Medicine, Vol. 150, No. 4, 10.1994, p. 956-961.

Research output: Contribution to journalArticle

Kanner, RE, Connett, JE, Altose, MD, Buist, AS, Lee, WW, Tashkin, DP & Wise, RA 1994, 'Gender difference in airway hyperresponsiveness in smokers with mild COPD: The lung health study', American Journal of Respiratory and Critical Care Medicine, vol. 150, no. 4, pp. 956-961.
Kanner, Richard E. ; Connett, John E. ; Altose, Murray D. ; Buist, A (Sonia) ; Lee, Wondra W. ; Tashkin, Donald P. ; Wise, Robert A. / Gender difference in airway hyperresponsiveness in smokers with mild COPD : The lung health study. In: American Journal of Respiratory and Critical Care Medicine. 1994 ; Vol. 150, No. 4. pp. 956-961.
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