Gastrointestinal stromal tumours: Origin and molecular oncology

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607 Scopus citations


Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of personalized treatment for cancer patients. The nearly simultaneous discovery of a biomarker that is reflective of their origin and the presence of gain-of-function kinase mutations in these tumours set the stage for more accurate diagnosis and the development of kinase inhibitor therapy. Subsequent studies of genotype and phenotype have led to a molecular classification of GIST and to treatment optimization on the basis of molecular subtype. The study of drug-resistant tumours has advanced our understanding of kinase biology, enabling the development of novel kinase inhibitors. Further improvements in GIST treatment may require targeting GIST stem cell populations and/or additional genomic events.

Original languageEnglish (US)
Pages (from-to)865-878
Number of pages14
JournalNature Reviews Cancer
Issue number12
StatePublished - Dec 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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