Gastrointestinal stromal tumours: Origin and molecular oncology

Research output: Contribution to journalReview article

453 Scopus citations

Abstract

Gastrointestinal stromal tumours (GISTs) are a paradigm for the development of personalized treatment for cancer patients. The nearly simultaneous discovery of a biomarker that is reflective of their origin and the presence of gain-of-function kinase mutations in these tumours set the stage for more accurate diagnosis and the development of kinase inhibitor therapy. Subsequent studies of genotype and phenotype have led to a molecular classification of GIST and to treatment optimization on the basis of molecular subtype. The study of drug-resistant tumours has advanced our understanding of kinase biology, enabling the development of novel kinase inhibitors. Further improvements in GIST treatment may require targeting GIST stem cell populations and/or additional genomic events.

Original languageEnglish (US)
Pages (from-to)865-878
Number of pages14
JournalNature Reviews Cancer
Volume11
Issue number12
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Fingerprint Dive into the research topics of 'Gastrointestinal stromal tumours: Origin and molecular oncology'. Together they form a unique fingerprint.

  • Cite this