Gastrointestinal involvement in Langerhans cell histiocytosis (histiocytosis X): diagnosis by rectal biopsy.

R. G. Lee, R. M. Braziel, P. Stenzel

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


We report two patients with biopsy-proven involvement of the gastrointestinal tract by Langerhans cell histiocytosis (LCH). The two patients were infants with congenital cutaneous lesions and bloody diarrhea beginning at 1 or 2 wk of age. Rectal biopsy specimens showed a mucosal infiltrate of typical Langerhans cells that focally invaded and destroyed the crypt epithelium. Gastrointestinal involvement by LCH is unusual and only rarely has represented a prominent clinical manifestation. In most cases, such involvement has been an indicator of widespread multisystemic disease. Its distinctive morphologic and immunohistochemical features allow LCH to be distinguished from other histiocytic infiltrations found in mucosal biopsy specimens.

Original languageEnglish (US)
Pages (from-to)154-157
Number of pages4
JournalModern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
Issue number2
StatePublished - Mar 1 1990

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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