Gastrointestinal dysfunction in the synucleinopathies

Kathryn A. Chung, Ronald F. Pfeiffer

Research output: Contribution to journalReview articlepeer-review

Abstract

Interest in gastrointestinal dysfunction in Parkinson’s disease has blossomed over the past 30 years and has generated a wealth of investigation into this non-motor aspect of the disorder, research that has encompassed its pathophysiology, its clinical features, and its impact on quality of life. The question of gastrointestinal dysfunction in the other synucleinopathies has not received nearly as much attention, but information and knowledge are growing. In this review, the current knowledge, controversies, and gaps in our understanding of the pathophysiology of gastrointestinal dysfunction in Parkinson’s disease and the other synucleinopathies will be addressed, and extended focus will be directed toward the clinical problems involving saliva management, swallowing, gastric emptying, small intestinal function, and bowel function that are so problematic in these disorders.

Original languageEnglish (US)
Pages (from-to)77-99
Number of pages23
JournalClinical Autonomic Research
Volume31
Issue number1
DOIs
StatePublished - Feb 2021

Keywords

  • Constipation
  • Dysphagia
  • Gastrointestinal
  • Gastroparesis
  • Parkinsonism
  • Synuclein

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Clinical Neurology

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