Gastrointestinal complications

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Gastrointestinal and hepatic complications are common in the hematopoietic stem cell transplant (HSCT) patient. The agents used in the conditioning regimen induce direct disruption of the intestinal barrier as well as indirect damage from cytokine release and generalized inflammatory state. These events lead to permeation of bacteria and endotoxins through the bowel wall, with subsequent organ damage and increased risk for infections. Similarly, HSCT conditioning can directly affect the hepatic parenchyma or hepatic sinusoids. The immunosuppressed state of the HSCT patient also increases the risk for opportunistic infections of the gastrointestinal tract and liver.

Original languageEnglish (US)
Title of host publicationBlood and Marrow Transplant Handbook
Subtitle of host publicationComprehensive Guide for Patient Care
PublisherSpringer New York
Pages223-231
Number of pages9
ISBN (Print)9781441975058
DOIs
StatePublished - Dec 1 2011

ASJC Scopus subject areas

  • Medicine(all)

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  • Cite this

    Nemecek, E. (2011). Gastrointestinal complications. In Blood and Marrow Transplant Handbook: Comprehensive Guide for Patient Care (pp. 223-231). Springer New York. https://doi.org/10.1007/978-1-4419-7506-5_18