Gastroenterology and neurology

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Purpose of Review: Just as gastrointestinal dysfunction may develop in the setting of neurologic disease, neurologic dysfunction may become evident in the setting of gastrointestinal disease. This article describes the range of neurologic features that have been described in three primary gastrointestinal diseases: celiac disease and gluten-related disorders, inflammatory bowel disease, and Whipple disease. Particular emphasis is placed on the controversial and evolving clinical picture of neurologic dysfunction in disorders of gluten sensitivity. Recent Findings: Gluten-related disorders, including both the traditional autoimmunebased celiac disease and the more recently recognized nonautoimmune, nonallergic gluten sensitivity, have been the source of much attention in both medical and lay publications. The possible association between Crohn disease and neurologic disorders also is receiving attention. The recognition that, although Whipple disease is an exceedingly rare disorder, a surprising percentage of the population may be asymptomatic stool carriers of the causative organism makes it important to always be cognizant of the disorder. Summary: The range of neurologic dysfunction in gastrointestinal diseases is broad and spans the spectrum from peripheral to central processes. Peripheral neuropathy, myopathy, myelopathy, cerebrovascular events, epilepsy, encephalopathy, and cerebellar dysfunction have all been described. Neurologists should be aware of the possibility that an underlying gastrointestinal disease process may be present in and responsible for the neurologic dysfunction that has prompted referral of an individual for evaluation.

Original languageEnglish (US)
Pages (from-to)744-761
Number of pages18
JournalCONTINUUM Lifelong Learning in Neurology
Volume23
Issue number3NeurologyofSystemicDisease
StatePublished - 2017

Fingerprint

Glutens
Gastrointestinal Diseases
Gastroenterology
Neurology
Neurologic Manifestations
Whipple Disease
Celiac Disease
Nervous System Diseases
Cerebellar Diseases
Spinal Cord Diseases
Brain Diseases
Peripheral Nervous System Diseases
Muscular Diseases
Inflammatory Bowel Diseases
Crohn Disease
Nervous System
Publications
Epilepsy
Referral and Consultation
Population

ASJC Scopus subject areas

  • Clinical Neurology
  • Genetics(clinical)

Cite this

Pfeiffer, R. (2017). Gastroenterology and neurology. CONTINUUM Lifelong Learning in Neurology, 23(3NeurologyofSystemicDisease), 744-761.

Gastroenterology and neurology. / Pfeiffer, Ronald.

In: CONTINUUM Lifelong Learning in Neurology, Vol. 23, No. 3NeurologyofSystemicDisease, 2017, p. 744-761.

Research output: Contribution to journalReview article

Pfeiffer, R 2017, 'Gastroenterology and neurology', CONTINUUM Lifelong Learning in Neurology, vol. 23, no. 3NeurologyofSystemicDisease, pp. 744-761.
Pfeiffer, Ronald. / Gastroenterology and neurology. In: CONTINUUM Lifelong Learning in Neurology. 2017 ; Vol. 23, No. 3NeurologyofSystemicDisease. pp. 744-761.
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