Gastric mucosal protection from enteral nutrients

Role of motility

Kimberly S. Ephgrave, Karen Brasel, Joseph J. Cullen, Kimberly A. Broadhurst

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Background: Cold restraint stress increases the force of gastric contractions and produces gastric mucosal injury in rats. The aim of our study was to determine whether enteral glucose or hyperglycemia alone would alter the stress-induced gastric motility pattern and ameliorate the associated gastric mucosal injury. Methods: Adult male rats underwent surgical placement of gastric catheters, jugular venous catheters, and gastric strain gauge transducers 5 days before cold restraint. Three groups of rats received different substances during the same cold restraint stress protocol. Group 1 received 0.9% NaCl, 2 mL/h infused both intravenously (IV) and intragastrically (IG); group 2 received 0.9% NaCl, 2 mL/h IG plus 25% glucose, 2 mL/h IV; and group 3 received 0.9% NaCl, 2 mL/h IV plus 25% glucose IG. Following baseline gastric motility measurements, all rats were restrained for 2 hours at 20°C followed by 2 hours at 4°C. Results: Restraint even at room temperature increased the force of gastric contractions; the cold environment gradually prolonged gastric contractions. Enteral glucose blunted the effects of stress on gastric motility, increased gastric residual volume, decreased gastric acidity, and prevented gastric mucosal injury. Parenteral glucose had little effect on any gastric parameters. Conclusions: Enteral glucose prevents the abnormal gastric motility pattern that is necessary to produce the gastric mucosal injury associated with cold restraint stress, but hyperglycemia alone has little effect on the pathophysiology of cold restraint.

Original languageEnglish (US)
Pages (from-to)434-440
Number of pages7
JournalJournal of the American College of Surgeons
Volume186
Issue number4
DOIs
StatePublished - 1998
Externally publishedYes

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Small Intestine
Stomach
Food
Glucose
Wounds and Injuries
Hyperglycemia
Catheters
Residual Volume
Transducers
Neck

ASJC Scopus subject areas

  • Surgery

Cite this

Gastric mucosal protection from enteral nutrients : Role of motility. / Ephgrave, Kimberly S.; Brasel, Karen; Cullen, Joseph J.; Broadhurst, Kimberly A.

In: Journal of the American College of Surgeons, Vol. 186, No. 4, 1998, p. 434-440.

Research output: Contribution to journalArticle

Ephgrave, Kimberly S. ; Brasel, Karen ; Cullen, Joseph J. ; Broadhurst, Kimberly A. / Gastric mucosal protection from enteral nutrients : Role of motility. In: Journal of the American College of Surgeons. 1998 ; Vol. 186, No. 4. pp. 434-440.
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