To determine the potential association of increased201T1 uptake by the stomach with symptoms referable to gastritis, 39 consecutive patients experiencing chest pain syndromes underwent a routine dipyridamole201T1 pharmacological stress test. With the patient in a fasting state, dipyridamole was infused intravenously (0.56 mg kg-1), shortly followed by201T1 infusion and subsequent image acquisition for single photon emission tomography (SPET). The original 32 SPET images over 180° of arc were interpreted without knowledge of clinical data, using a 4-point scoring system. Patients with active symptoms of gastro-oesophageal discomfort (n=17) were found to have significantly greater201T1 stomach uptake scores, compared to the little or no uptake in the 22 patients without such active symptoms (P=0.0001). A stepwise logistic regression analysis was used to determine which factor(s) showed independent predictive value of201T1 gastric uptake. The only two independent variables identified were the presence of active gastritis symptoms and the use of anti-gastritis medications. Elevated gastric201T1 uptake may be a clinically useful finding indicative of gastric inflammation that may be of value in the differential diagnosis of chest and epigastric discomfort.
ASJC Scopus subject areas
- Radiology Nuclear Medicine and imaging