Ganglionic and arterial release of neuropeptide Y by bullfrog sympathetic neurons

M. Richard Thorne, Susan Smith, John P. Horn

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


Sympathetic C neurons in lumbar paravertebral ganglia of the bullfrog have previously been shown to be vasomotor in function and to express neuropeptide Y (NPY). In the present experiments, a sensitive radioimmunoassay was used to measure the NPY content of ganglia and the descending abdominal aorta and to measure the overflow of NPY evoked by depolarizing concentrations of K+. Paravertebral ganglia 9 and 10 contain 3.1 pg NPY/μg protein and the aorta contains 0.18 pg NPY/μg protein. During 20-min depolarizations in high K+ (58 mM) Ringer, the ganglia released ∼ 5% of their NPY content and the aorta released ∼ 2% of its NPY content. Pretreatment of the tissues with Ringer containing 0.18 mM Ca2+, 8 mM Mg2+, and 1 mM Co2+ blocked the NPY release elicited by high K+. These findings provide further evidence that NPY is a postganglionic co-transmitter in sympathetic C neurons of the bullfrog.

Original languageEnglish (US)
Pages (from-to)231-236
Number of pages6
JournalJournal of the Autonomic Nervous System
Issue number3
StatePublished - May 15 1992
Externally publishedYes


  • Aorta
  • Bullfrog
  • Neuropeptide Y
  • Radioimmunoassay
  • Sympathetic neuron
  • Vasomotor neuron

ASJC Scopus subject areas

  • Neuroscience(all)
  • Physiology
  • Clinical Neurology


Dive into the research topics of 'Ganglionic and arterial release of neuropeptide Y by bullfrog sympathetic neurons'. Together they form a unique fingerprint.

Cite this