Gangliogliomas of the optic pathway

John D. Rolston, Seunggu (Jude) Han, Jennifer A. Cotter, Ivan H. El-Sayed, Manish K. Aghi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Gangliogliomas involving the optic apparatus are rare, with only 23 cases described in the literature to our knowledge. Because of their location, they are resistant to gross total resection and command careful consideration of adjuvant treatment. Here, we review the existing literature describing these cases, along with our own additional patient. Most patients (91.3%) with optic gangliogliomas presented with progressive visual disturbances, and the majority were male (69.6%), as with gangliogliomas in general. Ophthalmological evaluation is warranted in these patients, followed by neurological imaging (preferably MRI). Screening for neurofibromatosis type 1 (NF1) is essential, as NF1 patients represent a disproportionate number of optic ganglioglioma cases (13.0%). Gross total resection should be attempted only if vision is beyond salvage, as this can be curative. Otherwise, when serviceable vision remains, subtotal resection with adjuvant radiation should be carried out when feasible. Despite treatment, the prognosis remains mixed, with roughly one-third of patients progressing.

Original languageEnglish (US)
Pages (from-to)2244-2249
Number of pages6
JournalJournal of Clinical Neuroscience
Volume21
Issue number12
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Ganglioglioma
Neurofibromatosis 1
Radiation
Therapeutics

Keywords

  • Ganglioglioma
  • Optic glioma
  • Pituitary
  • Sella
  • Visual loss

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology
  • Physiology (medical)
  • Medicine(all)

Cite this

Rolston, J. D., Han, S. J., Cotter, J. A., El-Sayed, I. H., & Aghi, M. K. (2015). Gangliogliomas of the optic pathway. Journal of Clinical Neuroscience, 21(12), 2244-2249. https://doi.org/10.1016/j.jocn.2014.05.018

Gangliogliomas of the optic pathway. / Rolston, John D.; Han, Seunggu (Jude); Cotter, Jennifer A.; El-Sayed, Ivan H.; Aghi, Manish K.

In: Journal of Clinical Neuroscience, Vol. 21, No. 12, 01.01.2015, p. 2244-2249.

Research output: Contribution to journalArticle

Rolston, JD, Han, SJ, Cotter, JA, El-Sayed, IH & Aghi, MK 2015, 'Gangliogliomas of the optic pathway', Journal of Clinical Neuroscience, vol. 21, no. 12, pp. 2244-2249. https://doi.org/10.1016/j.jocn.2014.05.018
Rolston JD, Han SJ, Cotter JA, El-Sayed IH, Aghi MK. Gangliogliomas of the optic pathway. Journal of Clinical Neuroscience. 2015 Jan 1;21(12):2244-2249. https://doi.org/10.1016/j.jocn.2014.05.018
Rolston, John D. ; Han, Seunggu (Jude) ; Cotter, Jennifer A. ; El-Sayed, Ivan H. ; Aghi, Manish K. / Gangliogliomas of the optic pathway. In: Journal of Clinical Neuroscience. 2015 ; Vol. 21, No. 12. pp. 2244-2249.
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