Galloping ophthalmoplegia and numb chin in Burkitt lymphoma

Juan J Chan Lau, Craig Okada, Jonathan D. Trobe

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

A 57-year-old man developed complete bilateral ophthalmoplegia over a period of 10 days, together with bilateral facial pain and numbness of the chin. He had no other clinical manifestations. Findings on brain magnetic resonance imaging and spinal fluid formula from the first lumbar puncture were normal, but cerebrospinal fluid flow cytometry disclosed a kappa restriction monoclonal B-cell population, indicating malignant lymphoma. Computed tomography of the chest, abdomen, and pelvis then revealed multiple enlarged lymph nodes. Biopsy of an inguinal node showed findings consistent with Burkitt lymphoma. Within six weeks, intravenous and intrathecal chemotherapy resolved all neurologic findings except a partial right-side sixth nerve palsy and mild chin numbness. Eighteen months after disease onset, the patient remained in remission. Meningeal spread of Burkitt lymphoma is not commonly a presenting feature in immunocompetent adults. Chin numbness, a characteristic feature caused by infiltration of the mental nerve, should facilitate earlier recognition, which may be life saving.

Original languageEnglish (US)
Pages (from-to)130-134
Number of pages5
JournalJournal of Neuro-Ophthalmology
Volume24
Issue number2
DOIs
StatePublished - Jun 2004
Externally publishedYes

Fingerprint

Ophthalmoplegia
Chin
Burkitt Lymphoma
Hypesthesia
Abducens Nerve Diseases
Facial Pain
Spinal Puncture
Groin
Neurologic Manifestations
Pelvis
Abdomen
Cerebrospinal Fluid
Lymphoma
Flow Cytometry
B-Lymphocytes
Thorax
Lymph Nodes
Tomography
Magnetic Resonance Imaging
Biopsy

ASJC Scopus subject areas

  • Clinical Neurology
  • Ophthalmology

Cite this

Galloping ophthalmoplegia and numb chin in Burkitt lymphoma. / Lau, Juan J Chan; Okada, Craig; Trobe, Jonathan D.

In: Journal of Neuro-Ophthalmology, Vol. 24, No. 2, 06.2004, p. 130-134.

Research output: Contribution to journalArticle

Lau, Juan J Chan ; Okada, Craig ; Trobe, Jonathan D. / Galloping ophthalmoplegia and numb chin in Burkitt lymphoma. In: Journal of Neuro-Ophthalmology. 2004 ; Vol. 24, No. 2. pp. 130-134.
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