Gait and conditioned fear impairments in a mouse model of comorbid TBI and PTSD

Peyton Teutsch, Carolyn E. Jones, Mara E. Kaiser, Natasha Avalon Gardner, Miranda Lim

Research output: Contribution to journalArticle

Abstract

Study Objectives: Traumatic brain injury (TBI) and posttraumatic stress disorder (PTSD) commonly cooccur. Approaches to research and treatment of these disorders have been segregated, despite overlapping symptomology. We and others have hypothesized that comorbid TBI + PTSD generates worse symptoms than either condition alone. We present a mouse model of comorbid TBI + PTSD to further explore this condition. Methods: A mouse model of TBI + PTSD was generated using the single prolonged stress (SPS) protocol in combination with the controlled cortical impact (CCI) protocol. This resulted in four experimental groups: control, TBI, PTSD, and TBI + PTSD. Behavioral phenotyping included gait analysis, contextual fear conditioning, acoustic startle response, and prepulse inhibition. Results: Mice in the TBI + PTSD group showed a significantly impaired gait compared to their counterparts with TBI alone as well as control mice. Mice in the TBI + PTSD group showed significantly impaired contextual fear recall compared to controls. Prepulse inhibition testing revealed intact acoustic startle and auditory sensory gating. Conclusions: These results indicate that SPS paired with CCI in mice produces unique behavioral impairments in gait and fear recall that are not present in either condition alone. Further studies are underway to examine additional behavioral, physiological, and pathological phenotypes in this combined model of TBI + PTSD.

Original languageEnglish (US)
Article number6037015
JournalBehavioural Neurology
Volume2018
DOIs
StatePublished - Jan 1 2018

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Post-Traumatic Stress Disorders
Gait
Fear
Acoustics
Startle Reflex
Traumatic Brain Injury
Sensory Gating
Phenotype
Control Groups

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Neurology
  • Clinical Neurology

Cite this

Gait and conditioned fear impairments in a mouse model of comorbid TBI and PTSD. / Teutsch, Peyton; Jones, Carolyn E.; Kaiser, Mara E.; Gardner, Natasha Avalon; Lim, Miranda.

In: Behavioural Neurology, Vol. 2018, 6037015, 01.01.2018.

Research output: Contribution to journalArticle

Teutsch, Peyton ; Jones, Carolyn E. ; Kaiser, Mara E. ; Gardner, Natasha Avalon ; Lim, Miranda. / Gait and conditioned fear impairments in a mouse model of comorbid TBI and PTSD. In: Behavioural Neurology. 2018 ; Vol. 2018.
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