GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas

Anna Almeida, Xiang Xiao Zhu, Nicolas Vogt, Rachana Tyagi, Martine Muleris, Anne Marie Dutrillaux, Bernard Dutrillaux, Donald Ross, Bernard Malfoy, Samir Hanash

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

We have used two-dimensional electrophoresis of enzyme-digested genomic DNA to identify a novel gene GAC1, which maps at 1q32.1 and which is overexpressed in malignant gliomas in which it is amplified, GAC1 encodes a protein which belongs to the leucine-rich repeat superfamily. Amplification and overexpression of GAC1 was demonstrated in two of eight tumors where amplifications were previously evidenced by comparative genomic hybridization (one glioblastoma multiforme and one anaplastic astrocytoma), and in one of eight unselected glioblastomas multiforme. GAC1 exhibits sequence homology with other proteins which function as cell-adhesion molecules or as signal transduction receptor and is a likely candidate for the target gene in the 1q32.1 amplicon in malignant gliomas.

Original languageEnglish (US)
Pages (from-to)2997-3002
Number of pages6
JournalOncogene
Volume16
Issue number23
DOIs
StatePublished - Jun 11 1998

Keywords

  • Amplification
  • Chromosome 1
  • Glioma
  • Leucine-rich repeat
  • Overexpression

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

Fingerprint Dive into the research topics of 'GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas'. Together they form a unique fingerprint.

  • Cite this

    Almeida, A., Zhu, X. X., Vogt, N., Tyagi, R., Muleris, M., Dutrillaux, A. M., Dutrillaux, B., Ross, D., Malfoy, B., & Hanash, S. (1998). GAC1, a new member of the leucine-rich repeat superfamily on chromosome band 1q32.1, is amplified and overexpressed in malignant gliomas. Oncogene, 16(23), 2997-3002. https://doi.org/10.1038/sj.onc.1201828