GABA agonist

Clomethiazole

Anand Vaishnav, Helmi Lutsep

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Neuroprotective agents inhibit reactions in the brain ischaemic injury cascade which lead to neuronal death. Gamma-aminobutyric acid (GABA) is a naturally occurring inhibitory neurotransmitter that increases chloride influx into the neuron and counteracts the toxic effects of glutamate. Clomethiazole is a GABAA agonist, which causes membrane hyperpolarization, counteracting depolarization and the subsequent cascade of biochemical events that result in neuronal death. Promising results in animal models resulted in clinical trials conducted in humans. However, large randomized placebo controlled trials in Europe, Canada and North America did not show the superiority of clomethiazole over placebo that was seen in animal models.

Original languageEnglish (US)
JournalCurrent Medical Research and Opinion
Volume18
Issue numberSUPPL. 2
DOIs
StatePublished - 2002

Fingerprint

Chlormethiazole
GABA Agonists
Animal Models
Placebos
GABA-A Receptor Agonists
Poisons
Neuroprotective Agents
North America
Brain Injuries
gamma-Aminobutyric Acid
Canada
Neurotransmitter Agents
Chlorides
Glutamic Acid
Randomized Controlled Trials
Clinical Trials
Neurons
Membranes

Keywords

  • Clomethiazole
  • GABA
  • Neuroprotection
  • Stroke

ASJC Scopus subject areas

  • Medicine(all)

Cite this

GABA agonist : Clomethiazole. / Vaishnav, Anand; Lutsep, Helmi.

In: Current Medical Research and Opinion, Vol. 18, No. SUPPL. 2, 2002.

Research output: Contribution to journalArticle

Vaishnav, Anand ; Lutsep, Helmi. / GABA agonist : Clomethiazole. In: Current Medical Research and Opinion. 2002 ; Vol. 18, No. SUPPL. 2.
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